$ 20.15 $ 22.17
Liposomal Delivery System
Liposomal delivery significantly enhances absorption. A liposomal liquid delivery system allows for flexible, convenient dosing of Melatonin in order to address individual requirements. Liposomal technology helps to maintain the health benefits of Melatonin by protecting it from the degradative environment of the stomach. This is especially beneficial for patients who have had gastric bypass or general gastro-intestinal dysfunction.* Liposomal encapsulation of ingredients represents a new delivery system that appears to offer important advantages over existing methods of delivery.*
A dietary supplement that promotes resilient homeostasis, deep restful sleep, provides pivotal support for core immune functions and balance, stimulates vital internal cell production of glutathione, and provides for enhanced repair after assorted types of radiation exposure.*
The level of melatonin produced by the body is heavily influenced by sunlight, sleep and artificial light. At night, the secretion of melatonin is much higher than during the day. When this process is interrupted, certain symptoms can occur such as: (a) disruptions in the sleep/wake cycle, (b) headaches, (c) mental and physical fatigue and (d) irritability.*
Melatonin levels decline as we age by as much as 90% by age 45.*
What is Melatonin?
Melatonin is the principle hormone produced and secreted by the brain’s pineal gland. As a hormone, melatonin's wide-spread effects are comprehensive, and perhaps most intriguingly include (1) regulation over genetic regenerative repair. Two other most important upstream functions are (2) melatonin's command and control over the body's biological clock, known as the circadian rhythm. More on this below. The third most important upstream function is that melatonin serves as (3) the chief determinant over the production of vital intracellular production of glutathione. Intracellular levels of glutathione control the balance and proper regulation of TH-1 verses TH-2 immune cells, which play central roles in many autoimmune diseases.*
Very important downstream functions that are heavily influenced and regulated by the above, are melatonin's ceaseless regulation of the (4) endocrine system and (5) many metabolic pathways, plus its ability to (6) chelate and excrete deeply ingrained body stores of heavy metals such as mercury. For this reason, Melatonin is often given with NanoZeolite MD.*
Why else is it important to supplement with Melatonin?
Melatonin serves an unsurpassed role to check, balance and repair insults from radiation exposure, both ionizing as well as non-ionizing.*
Sleep Quality and Circadian Rhythm
It turns out that all body functions and homeostasis is under the powerful influence of an internal clock referred to as our circadian rhythm. More specifically, the circadian rhythm refers to time-sensitive and seasonal-sensitive variations to cell physiology. Darkness stimulates the release of melatonin and light suppresses its activity. Normal melatonin cycles and circadian rhythm are disrupted when we are exposed to excessive light in the evening or too little natural light during the daytime.*
The master pacemaker of the circadian rhythm is the suprachiasmatic nucleus that receives the information from environmental cues and communicates the timing information to the peripheral clocks in every cell, every tissue and every organ through the endocrine and autonomic nervous system. Desynchronization of these rhythms and disease is now pervasive in our society, given exposure to light at night and disruptive sleep schedules.*
In a very real sense, melatonin "synchronizes" sleep/wake cycles, food intake habits, and hormone cycles to the 24 hour daily period.*
For example, decades of research shows that sleeping 8 solid hours without waking is critical to human health. As our body sustains trillions of molecular injuries and mutations daily, continuous 8 hours of sleep is essential for complete repair.
During continuous sleep, the body also recovers and recharges organ systems including the immune system, adrenals, and cellular metabolism.*
Losing weight, defending ourselves from microorganism and managing rogue cell cycles are severely compromised when sleep is disturbed.*
Melatonin plays an important role to both induce good restful sleep as well as to awaken us in a timely manner in good spirits.*
Melatonin supports sleep onset and quality of sleep and increased Rapid Eye Movement time, deep sleep and dreaming.* These changes demonstrate better quality sleep, which produces greater mental, physical and emotional rejuvenation.*
Melatonin can decrease the amount of time required to fall asleep, increase the number of sleeping hours and support daytime alertness.*
Jet Lag and Rotating Shift Work
Jet lag and rotating shift work can interfere with the body’s natural circadian rhythm. Melatonin supports quality sleep and balanced circadian rhythms in people with disrupted circadian rhythms (such as those suffering from jet lag or poor vision or those who work the night shift) and those with low melatonin levels (such as some elderly). Taking just 3mg of Melatonin at bedtime may reduce the stress and help re-establish the natural circadian rhythms when confronting these conditions.*
Melatonin is also one of the hormones that controls the timing and release of female reproductive hormones. It helps determine when menstruation begins, the frequency and duration of menstrual cycles, and when menopause begins. It’s a powerful regulator of sex hormone production and can effect mood, immunity, reproduction and bone health. Supplementing just 3mg of Melatonin at bedtime may benefit menopausal women by supporting and sustaining sleep and by supporting osteoblasts that support bone health.*
Immune and Antioxidant Support
Melatonin has strong antioxidant properties and helps support immune system strength.* As an antioxidant it is 6 to 10 times more potent than vitamin E and is one of the few antioxidants that can enter the mitochondria to protect it from free radical damage.* Taking from 3mg to as much as 100mg daily has been used clinically to augment superior immune surveillance and functionality of nearly all bodily antioxidant systems.*
Some people experience a depressed mood when the low sunlight levels (winter) are not sufficient for their pineal glands to decrease melatonin production to its normal low daytime level. Supplementing with just 3mg of Melatonin can support mood balance seasonally or in times of low mood.*
Protection from Chronic Low-level Radiation
Studies demonstrate that exogenous melatonin reduces oxidative stress and inflammation in all investigated animal tissues. Furthermore, in this study melatonin increases 30-day survival and protected against radiation enteritis. Melatonin protected healthy tissues from ionizing radiation. These protective effects were only documented when melatonin was administered prior to exposure to ionizing radiation.*
In human studies, oral melatonin uniformly protected cellular DNA from ionizing radiation from Cs137 or x-rays. This is thought to be related to a direct free radical scavenging effects. Melatonin is thought to have major potential to protect against increased long-term cancer risk in radiological imaging procedures, and to protect from radiation due to nuclear incidents.*
The best way to regenerate the body and stay healthy is to:
When the above behavior modifications are compromised, one should use Blue-Light protective glasses and melatonin.*
Other ingredients: glycerin, water, sunflower lecithin, oleic acid polyglyceride, citric acid, xanthan gum, orange oil, rosmarinic acid, rice flour, gelatin.
Supplement Facts Serving Size: 2 sprays (0.4 ml) Amount Per Serving Melatonin 3 mg, or as directed by your health care provider.
Each serving contains 3 mg of the highest quality synthetic Melatonin in a liposomal delivery system.
Warning: This product should not be taken by adolescents, pregnant or lactating women, persons taking cortisone, or persons with kidney disease. Consult your physician if taking medications for sleep, anxiety or if on any anti-coagulant, antidepressant, antipsychotic or anti-hypertensive drugs.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease
Exp Gerontol. 1998 Nov-Dec;33(7-8):759-72.
Age-related changes in melatonin levels in humans and its potential consequences for sleep disorders.
Waldhauser F, Kovács J, Reiter E.
Karasek, M, Melatonin, human aging, and age-related diseases. Exp Gerontol. 2004 Nov-Dec;39(11-12):1723-9.
Zetner D, Andersen LP, Rosenberg J. Melatonin as Protection Against Radiation Injury: A Systematic Review. Drug Res (Stuttg). 2016 Jun;66(6):281-96. doi: 10.1055/s-0035-1569358. Epub 2016 Jan 20.
Russel J.ReiterAhmetKorkmazShuranMaSergioRosales-CorralDun-XianTan, Melatonin protection from chronic, low-level ionizing radiation, Mutation Research/Reviews in Mutation Research, Volume 751, Issue 1, July–September 2012, Pages 7-14
Eugene AR, Masiak J. The Neuroprotective Aspects of Sleep. MEDtube science. 2015;3(1):35-40.
Bellesi M, Bushey D, Chini M, Tononi G, Cirelli C. Contribution of sleep to the repair of neuronal DNA double-strand breaks: evidence from flies and mice. Scientific Reports. 2016;6:36804. doi:10.1038/srep36804.
Parveen Bhatti, Dana K Mirick, Timothy W Randolph, Jicheng Gong, Diana Taibi Buchanan, Junfeng (Jim) Zhang, Scott Davis. Oxidative DNA damage during night shift work. Occupational and Environmental Medicine, 2017; oemed-2017-104414 DOI: 10.1136/oemed-2017-104414
Carrillo-Vico A, Lardone PJ, Álvarez-Sánchez N, Rodríguez-Rodríguez A, Guerrero JM. Melatonin: Buffering the Immune System. International Journal of Molecular Sciences. 2013;14(4):8638-8683. doi:10.3390/ijms14048638.
Pregnenolone is often referred to as the “mother hormone” since it is the first hormone at the top of the cascade that makes progesterone, cortisol, DHEA, testosterone and all estrogens. It’s role in the adrenal-cortisol pathway includes supporting a wide range of anti-inflammatory functions including memory, cognition, immune function, joints and energy.*
Pregnenolone belongs to a group of neurosteroids (like DHEA, DHEA-S, and progesterone) that are in high concentrations in certain areas of the brain. These protect the nerve cells and enhance myelination. Pregnenolone is lipophilic and crosses the blood-brain barrier to support memory and cognition.*
In clinical practice, when serum pregnenolone levels are in the lowest quartile before 8 AM, consideration should be given to full adrenal support which includes:
I have found pregnenolone to be a life-saver for patients who have low serum levels and adrenal dysfunction. Once the adrenal function is recovered, patients can reduce and discontinue supplementation.*
This is a fully vegan formula.*
Standard Dosage is 50 mg in AM and/or PM depending on individual effects and as directed by your healthcare provider.
For a full understanding of optimizing energy, watch “Tired of Being Tired”
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Micronized Dehydroepiandrosterone, better known as simply DHEA‚ should be understood as being the most abundant adrenal steroid hormone in the body. Our DHEA is made from natural wild yams. DHEA is the key basic material utilized by the adrenal glands for conversion into the all-important steroids: cortisol, testosterone, estrogens, and others. Just as importantly, the adrenals also secret DHEA directly into the blood stream, where similarly distal target cells throughout the body convert it into testosterone, estrogens and other hormones. The amount of each hormone that DHEA creates during the conversion process depends on an individual’s nutrient status‚ stress, age‚ and sex. Normally DHEA levels peak at around age 25‚ and then decline steadily to approximately 20% of normal levels by the Age of 70 (6). For those with additional stress, DHEA will decline more rapidly.*
Therefore, because DHEA serves as a substrate to so many vital steroids essential to adapting to stress, approximately 50% or more of our most stressed patients reveals labs that show DHEA deficiency and are subsequently placed unto DHEA.*
DHEA is a major adrenal hormone which supports the cortisol pathway and fundamental anti-inflammatory mechanisms in the body (12,13). Supplementing with DHEA can promote lean muscle mass, energy, stamina, sexual function, mood, immune function, circulatory health, joint health, hormone levels and more.* Studies suggest that DHEA can aid and facilitate:
DHEA: usage and safety precautions
DHEA-S blood levels should be measured and monitored to determine individual needs. The dosage increases in low adrenal states. The normal dose should be determined after discussion with your health-care provider. The average recommended dose is between 25 mg and 50 mg orally per day either divided in AM and noon or all in the AM.*
Additional support of adrenal function should include 1) optimization of all hormones including thyroid; 2) nutrient measurement and correction of deficiencies; 3) optimizing detoxification and pH; 4) balancing the mind stressors; and 5) reducing the body stressors with oxygenation.
For further information on protocols for the adrenal glands please see
Welcome to MdPrescriptives!
Sign up below to subscribe to our e-mail list for special discounts, events, upcoming webinars on regenerative medicine, and much more