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Promotes Healthy Response to Stress
NEW & IMPROVED!!! A comprehensive blend of the highest-quality adaptogenic herbs. These ingredients aid in adrenal hormone production and support the body's adaptogenic response. Also unlike many adrenal formulas on the market, Adrenal Forte is fully vegan.*
A complete adrenal and adaptogenic solution in one bottle! This formula incorporates the latest scientific research on nutrition and metabolic functions. Individual nutrients are formulated for maximum bioavailability, synergy and hormonal activation.* Specific features include:
Cordyceps sinensis (mycelium extract standardized to 7% cordycepic acids) - Both in vitro and in vivo animal studies have confirmed that Cordyceps sinensis helps stimulate adrenal function and promote healthy levels of cortisol production. One controlled, randomized human study showed that Cordyceps sinensis significantly reduced the pro-inflammatory biomarkers IgE, ICAM-1, IL-4, and MMP-9 while also reducing long-standing mild to moderate inflammatory lung conditions. Cordyceps is regarded as a very precious medicinal mushroom in China and other Asian countries. For over 2000 years, Cordyceps sinensis has been used as a tonic, to increase health and vitality, combat aging and help against various age-related diseases. It is a safe, highly valued herb with activities that support nearly every physiological system impacted by the body’s response to normal everyday stressors, including the immune and cardiovascular systems. In addition the cell-protective and antioxidant activities of Cordyceps have been well documented.*
Rhodiola rosea (root extract standardized to 3% rosavin & 1% salidroside) - A number of studies have shown that Rhodiola can dramatically reduce mental and physical fatigue under stressful conditions by increasing the body’s energy levels. It is believed that Rhodiola enhances the body’s tolerance to stress by influencing key brain chemicals, such as serotonin and norepinephrine, and natural feel-good opioids such as beta-endorphins. Recent studies reveal this herb's medicinal properties include anti-aging effects, anti-inflammatory effects and strong anti-stress effects. The main medical constituents of this herb are eight in number, including rosarin, rosavin, rosin, salidroside, tyrosol, rhodionin, catechin and gallic acid. It also possesses several other significant antioxidants. Rodiola stimulates immunity, enhances DNA repair and modulates adaptation to hypoxia and angiogenesis. According to a comprehensive review of the literature on Rhodiola, supplementation provides cognitive stimulation and supports healthy work performance, quality of sleep, emotional calming, appetite, and energy levels subsequent to intense physical or intellectual strain.*
Panax Ginseng - Red Ginseng (root extract standardized to 80% ginsenosides) - Studies show that ginseng and it content of ginsenosides have beneficial effects in supporting the adrenal glands and upregulates genes related to catecholamine production. The herbs also protects the gastric mucosa, and supports healthy body weight and an array of blood hormones. Ginsenosides also support the immune system and have cytokine-modulating activities. has been used in medicine for over 5000 years. In summary, Panax enhances athletic performance, and provides energy to people who are stressed or fatigued.*
Siberian ginseng - Eleutherococcus senticosus/Acanthopanax senticosus (root & stem extract standardized to 0.8% Eleutherosides B & E; ) - Is not actually ginseng, but rather a different plant species. It contains eleutherosides and ciwujianosides as opposed to ginsenosides. Both stimulate cortisol production during exercise, energy and lessen fatigue. Additionally, this herb is well-known to support the immune system. Eleuthero has also been associated with increased mental ability, concentration and greater alertness.*
Ashwagandha - Withania somnifera (root extract standardized to 1.5% Withanolides) - Aswagandha is one of the most vital herbs in Ayurvedic healing, has been used since ancient times for a wide variety of conditions, but is most well-known for its restorative benefits. It is the ginseng of the Ayurvedic medicine. A comprehensive cortisol study in mice revealed Ashwaganda extract reduced fatigue and increased stamina while increasing levels of circulating cortisol. One recent human clinical study showed that it promoted restoration to healthier levels four adrenal hormones. Specifically in this single case study, Ashwanganda helped normalize 3-β-ol dehydrogenase deficiency and aldosterone synthase deficiency. In general, the herb helps improve physical energy and athletic ability, increase immunity to those common winter challenges and increase sexual capacity and fertility. Ashwaganda seems to show positive effects on the endocrine, cardio, and central nervous systems. It is one herb that could help your body produce its own thyroid hormones.*
Standard Dosage: Take four capsules daily in divided doses or as directed by your healthcare practitioner.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
References
Kalani A, et al. Ashwagandha root in the treatment of non-classical adrenal hyperplasia. BMJ Case Rep. 2012; 2012: bcr2012006989.
Sudhir S, Budhiraja RD. Comparison of the Protective Effect of Withanferin-A and Hydrocortisone Against CCL4 Induced Hepatotoxicity in Rats. Indian J Physiol Pharmacol. 1992 Apr;36(2):127-9.
Essentials 5 in 1 DR (Delayed Release) is our premier multi-vitamin-mineral rich product. Incorporates the latest scientific research on nutrition and metabolic functions. Individual nutrients are formulated for maximum bioavailability, synergy, hormonal/metabolic activation and antioxidant capacity. Now in delayed release capsules to minimize or completely eliminate the gastric side effects some individuals experience taking a multivitamin.*
Essentials 5 in 1 is a complete multinutrient designed specifically for maximum hormonal and metabolic activation in one bottle, virtually eliminating the need for additional supplemental Vitamin B, Vitamin E, Vitamin A, Vitamin K, and extra minerals.*
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
REFERENCES
Magnesium MD Customer Sell Sheet
REFERENCES
We are very pleased to inform you we have produced a truly superior PureBiotic™ formula:
MORE POTENT · LESS CAPSULES · MORE EFFECTIVE SPECIES · OPTIMIZE IMMUNITY · MORE REGENERATIVE IMPACT · SAME PRICE!
Natural Full Spectrum Probiotic Blend Featuring 15 Probiotic Species Blended to Attain +28 Billion CFU per Serving
Our new advanced PureBiotic™ formula optimally promotes quenching systemic inflammation, supporting superior immune system functions while facilitating better digestive functions than ever before. It remains the ideal choice for individuals with poor B-vitamin status, or for those production who recently have undergone antibiotic therapy. Our new formula maximally supports against gut microbial overgrowth (dysbiosis), constipation, diarrhea, and of course all gut conditions associated with gastro-intestinal inflammatory states.*
Our New Specific Formula Advantages Now Includes 5 different Bifidobacterium:
In general, Bifidobacteria are among the best colonizers of the human gut, especially with continued supplementation.1,2 For perspective, Bifidobacteria are considered by some scholars to be more important to human gut health than contributions made by the Lactobacillus group.3 In breast-feeding infants, nearly 100% of probiotics colonizing the gut are Bifidobacteria, and climb to between 1010 to 1011 CFU/gram of the breast-fed infants’ feces.4 Several of their pan-functions are to digest carbohydrates, manufacture B-complex vitamins, protect the gut from microbial invasion, reduce episodes of diarrhea, provide anti-mutagenic protection, and to build up and mature the immune system.5 By adulthood, Bifidobacteria will comprise only 5% to 10% of the total gut microbiota.*6
Among the more prevalent Bifidobacterium residing in the human gut, from infancy into adulthood, are:*
1. Bifidobacterium bifidum – This specie has been extensively studied and has excellent ability to colonize the gut. Studies show it was among the top in persisting in the feces after over 3 weeks from when supplementation had ceased.*7
2. B. breve - is also known to be immediately taken up and colonize the gut of new born infants.*8
3. B. longum – As mentioned above, studies reveal that B. longum is one specie that is persistent in the gut into adulthood. It is considered to be the most prevalent in the human gut of all the Bifidobacteria.9 The specie possesses remarkable immune modulating effects throughout the life of the host. B. longum has good ability to colonize in the gut after supplementation has ceased.*10
4. B. animalis lactis (VK2) – A study in combinations of select probiotics have shown that B. animalis lactis, when combined with L. acidophilus, can have up to 90% effectiveness in helping to eradicate H. pylori overgrowth.*11
5. B. lactis (BI-04) – This bacteria has an unusually high tolerance exposures to both high concentrations of oxygen and acid, leaving it very desirable to ferment milk products. B. lactis is most prevalent in human infants.*12
Into adulthood, Bifidobacteria continue to promote a long list of health benefits, but decline in overall numbers by at least one order of magnitude. On the other hand, Lactobacillus colonization escalates and will attain approximately 107 CFU/gram of feces.13 Both genus do not promote any kind of deleterious effects on the human being.*
However, both Bifidobacteria and Lactobacillus are greatly outnumbered by a variety of other not-so-friendly (opportunistic or pathogenic) gut microbes by approximately 8 to 1. Overall the gut will contain from 100 to 400 Trillion microbes, or about 10X to 40X the number of total human cells in the body. So, the main job of both Bifidobacteria and Lactobacillus is to help reign-in rogue microbial actions which might otherwise turn against regions of human tissues.*
Our New PureBiotic™ formula has 8 of the more studied Lactobacillus spp. Among the more common of Lactobacilli found in the human gut when consuming healthy diets are:*
6. Lactobacillus acidophilus (LA-14) – has the ability to temporarily populate deeply into the human gut. Interestingly, when it does so, the numbers of Lactobacilli in the gut soar after only 7 days of supplementation, but returns to their prior levels after 9 days after L. acidophilus supplementation is stopped. Therefore, this implies that to keep the numbers of lactobacilli up to optimal, L. acidophilus should be taken regularly with other lactobacilli.*14
7. L. helveticus – the specie is renown for impacting the immune system in a multifunctional capacity in that both a variety of healthy bacteriocins as well as a fleet of bioactive peptides are secreted in abundance. In general, L. helveticus colonizes the human gut adequately to perform a plethora of health benefits.*15
8. L. plantarum (LP-115) – is a specie well known to be able to pass through the upper intestinal tract to freely colonize the human gut. Several researchers have pointed out the L. plantarum acts similar to a living vaccine, providing ongoing immune modulation when and as needed.*16
9. L. rhamnosus (LR-32) – is an excellent species to promote healthy modulation in hyperimmune state. For example, L. rhamnosus is known to balance and calm T-cell hyperactivity associated with hyperimmune states. More specifically, L. rhamnosus modulates the pre-cursor dentritic cells (DCs), which in turn calm the T-cell population contributing to the hyperimmune states.*17
10. L. salivarius (LS-33) – this species is among the most populated in the human oral cavity. It protects against dental cavities and promotes healthy oral immunity.*18
11. L. casei (LC-11) – in a way similar to L. rhamnosus, L. casei calms skin contact hypersensitivity conditions, though beneficially modulating DCs.*19
12. L. bulgaricus (LB-64) – species is a very important probiotic to enhance the digestion of cows milk. L. bulgaricus is known for abundantly producing highly bioactive proteases very helpful to aid digestion of cheeses and milk.*20
13. L. brevis – this specie is known for secreting a powerful immune modulating brevican which helps check unfriendly gut bacteria such as E. coli and especially Staphylococcus aureus.*21
Finally, our new PureBiotic™ contains two remarkable probiotic species that have a synergistic interface, offering the host considerable defense against opportunistic microbes.*
14. Lactococcus lactis – This species is very common to cultured milk products and acts as a nature preservative. Other features include its production of an abundance of immune modulating bacterocidins.*22
15. Streptococcus thermophilus (ATCC 5B5207) – Both Lactococcus lactis and Streptococcus thermophilus offer unique protections to their host by way of their secreted phages which interface and knock-down unfriendly bacterial phages which can cause severe gut inflammation.*23
MORE POTENT - Potency is not just about the CFU count (colony forming units), but also about the ability of the individual species to survive and pass through your patient’s stomach acid and take up residency (colonize) their 20+ feet of gut lining.*
So, how can you tell if a high CFU count probiotic has effective species that do indeed pass on through to deliver alive probiotics into your patients’ entire digestive system? Simply put, it is about (A) lactic acid production (temporary gas!) and (B) achieving swifter successful outcomes.*
For example, many patients will report that when first taking a more potent probiotic they experience gas initially, even cramps, which soon subside. This well-known temporary effect indicates that the all-important pH of the gut is being favorably modified.24 Just imagine when baking soda comes into contact with vinegar, and you get the idea. pH is critical to gut health or ill-health, to enable patients to recover from long-term ingrained immune dis-regulation or not, as well as whether regenerative effects can be achieved in those patients or not.*
Other patients will experience more significant detoxification events, such as mild headaches, temporary nausea or transient looser stools. More rarely your patients with long-term microbe stresses may experience generalized achiness, malaise and mild night sweats as probiotics correct the gut microbiota.*
In patients long established on other probiotics, they too may notice more gas production or mild detoxification symptoms when taking a more potent and effective probiotic formula such as PureBiotic™.*
Other indicators your patients are achieving better results with the new PureBiotic™ formula would be evidence of more efficacious outcomes, especially when managing your patients with the 5 Point Model System. Difficult cases will often bear evidence they are healing faster than before when dosing PureBiotic™ optimally.*
Any one or more of these symptoms above is how you know that, in fact, you are giving them a more potent and effective probiotic product than the prior one they were given.*
Because our new PureBiotic™ formula is more potent, it is important to more carefully manage patient experiences with their new inoculation of superior probiotics. Simply giving them a heads-up usually suffices, along with instructions to drink more water. When cleansing or detoxification reactions still occur, reducing dosage or skipping days in between dosage makes this adjustment period easier and more comfortable to accomplish in your patients. It is well worth the effort to do so, since better outcomes will soon become evident.*
And as just mentioned above, a third indicator would be achieving regenerative healing, such as unscheduled healing (tough conditions thought by consensus to never heal, are in fact healed; for example, ingrained non-healing rectal wounds or fissures). Regenerative healing always involves enhanced detoxification, remodulation of gut microbiota, enhanced liver function, enhanced metabolic performance (i.e., better blood fat/ blood sugar regulation), enhanced immunity, and proper absorption and utilization of ‘regenerative nourishment’, all promoted by a superior probiotic formula.*25
More on this aspect as to how select probiotics such as those found in our new PureBiotic™ formula support regenerative healing is discussed below.*
LESS CAPSULES - Survey after survey shows that patients prefer to take less capsules per day rather than more capsules of any given formula. Therefore, we designed and crafted PureBiotic™ to be more convenient for your patients by reducing our recommended serving dose down from 3 capsules daily to just 2 capsules daily. But to preserve all prior benefits, and yet boost even more benefits, we found we could only do this by: (1) retaining all prior probiotic members, (2) adding in three more health promoting species, and (3) increasing the potency per capsule. In fact, with your patients taking only 2 capsules daily now of our new formula they receive 1 billion more CFU count compared to before that when they were taking 3 capsules daily! In summary, with our carefully selected and coordinated combination of probiotic species, they now receive over 28 Billion CFU per serving from our new PureBiotic™ formula.*
MORE EFFECTIVE SPECIES - With thousands of our patients having benefited from the original PureBiotic™ formula, we made sure to keep all of the original 12 individual probiotic species in our new formula.
Additionally, we added three superior probiotic species (Lactobacillus helveticus and L. brevis, plus Bifidobacterium animalis lactis) to enhance immune functions, promote mental well-being, focus and calm, and enable regenerative effects to better initiate body-wide.26,27,28,29,30,31 Stay tuned for more info on these wonderful critters in follow-up emails.*
But at this moment, in order to give you a clear clinical picture on the impact that PureBiotic™ is bound to have in your patients, it would be best to review the two-fold primary effects of probiotics – (A) gut microbiotaA reconditioning including gut pH modulation, and (B) immune optimization. Both these primary effects provide the foundation to the practice of regenerative medicine. There is the age-old dictum that death begins in the gut attributed to Hippocrates.32 But we say, regeneration must also begin in the gut. In fact, the word probiotics derives from “probios” which means, conducive to life, after Metchnikoff). So, what must we know to initiate from the deepest, most inner recesses of the body true and sustained regenerative healing? We must know and master the use of probiotics!*
To understand the inner most workings of regenerative medicine stemming from the gut, we must begin with the basics. Feces are 90% water, 9% bacteria (good or bad) and only 1% fiber. So, optimal ingestion of water is key to optimize all probiotic supplementation outcome. Next, living fecal bacteria can only come from colonized gut microbes (the patients’ gut microbiota). If those colonized microbes have been producing harmful wastes and pH values along any section of the gut, the patient cannot properly heal themselves and is actually hastening their own ill-health.*33
PureBiotic™ places (right where it counts the most), 15 very powerful probiotics that both (A) out-compete those unhealthy microbes while correcting the gut pH,34 as well as (B) optimize immune functions.35 And remember, with such a potent probiotic formula, the diet must contain best nourishment for these health promoting species. Fiber therefore is quintessential to optimizing PureBiotic™ colonization into your patients’ gut. So, it is good to know that each capsule of PureBiotic™ contains a hefty dose of F.O.S., a preferred fiber happily eaten by PureBiotic™ microbes to enhance your patients’ gut colonization.36 In this manner and in this manner only, can your patients’ gut microbiota and pH become optimized, and enhanced immunity initiate.*37
SYMPTOMS TO EXPECT - As a direct result, with such a more potent formula, you can expect to see greater impact on:
(1) normalizing constipation quicker (e.g., more frequent bowel movements, easier bowel movements, less stinky bowel movements, etc.).*
(2) correcting liver function, first confirmed by observing mild liver cleansing reactions, which typically may manifest as temporary mild nausea. This nausea will pass in a few days with persistent daily use of our new PureBiotic™ recommended dosage level.*
(3) temporary increased gas production, which likewise will also will pass away and cease over the first week or two of supplementation.*
We see about 15% to 20% of our patients experience one or more of these kind of cleansing symptoms when using PureBiotic™. You will too. When these signs and symptoms do arise, it is a clear indication of increased therapeusis instilled into our new formula. Just have the patient drink more water, eat a high fiber diet and temporarily reduce dosage as prudent until the patient is able to tolerate optimal dosage.*
OPTIMIZE IMMUNITY – Select probiotics found within PureBiotic™ have been carefully selected to stimulate beneficial immune responses by the white blood cells. Three precise mechanisms stand out as to how probiotics enhance immune functions. In addition to probiotics’ secretions that target direct intervention against noxious members of the gut microbiota,38 since 2000, elegant studies have decisively demonstrated that probiotics induce both innate and adaptive immune responses. Enhanced, induced innate immune responses would include probiotics’ ability to both upregulate immune cells’ respiratory burst and Phagocytic Index.39 Enhanced, induced adaptive immune responses would include probiotics’ ability to upregulate ‘balanced’ immune cell cytokine production and chemokine dynamics,40 as well as to induce immune tissues to secrete protective anti-microbe agents and/or activate and launch armies of fresh immune cells.41,42,43,44,45 Together, these mechanism bring about a modulation of the entire body’s gut microbiota which lessens deleterious members and increases symbiotic members.*
REGENERATIVE IMPACT – Over time, this symbiosis between colonized probiotics triggering enhanced performance by immune cells, engages regenerative activities that impact the entire body. But one may ask how does this actually come about? Recall that the intestinal tract from mouth to anus is considered the exterior part of the intestines, since it is in continuous contact with the external environment. This is termed the brush border. And recall that as food passes through this brush border to the other side, this other side (the interior intestinal region) is completely inundated, coated if you will, with approximately 70% of all immune cells by quantity. This enormous number of immune cells numbering in the high billions are voraciously awaiting to engulf regenerative effectors (food factors rich in growth factors), to speed and enhance their primary job of repair and systemic regeneration.*46
The carcasses (antigens) and immunomodulating actions and secretions of the beneficial probiotics, are taken up by the awaiting immune cells stationed along the 20+ feet of the interior/internal intestinal region.47 For example, the probiotic antigens when engulfed by the awaiting immune cells trigger a regenerative healing sequence, starting with promoting secretion of cytokines by the immune cells themselves, due to the probiotics’ immune-stimulating antigenic nature.48,49,50 The more these immune cells feast on the probiotic carcasses, the greater their production of beneficial cytokines. Cytokines are also known as growth factors, and for good reason. Growth factors are the core foundation to regenerative healing in the body. Other growth factors secreted by probiotics that are not strictly cytokines, but yet induce rapid healing, are L-lactic acid and butyric acid. Growth factors awaken adult stem cells (e.g., osteochondroprogenitor cells).51 If the diet is also adhering to the principles of the 5 Point Model System of regenerative medicine, additional growth factors from the diet join these white blood cells own production of growth factors of probiotic etiology,52,53 and the stage is set for high-gain targeted tissue regeneration.*54,55,56,57
Put another way, gut-associated cells feasting continually on:
(A) adequate levels of incoming dietary raw embryonic foods, such as blue-green algae58, mushrooms, bee pollen, freeze-dried glandular meats, etc., (collectively termed colloidal Regenerative Factors – cRFs)59 PLUS
(B) on growth factor stimulating probiotic secretions and carcasses60…
… induce target tissue specificity into immune cells to (i) heighten repair to optimal, (ii) reduce all biomarkers to aging (e.g., phase angle index, etc.) and (iii) mimic the core regenerative mechanisms of the long-living. More on this later.*
THERAPEUTIC INDEX – The long-living people from around the world are in fact the original source of our probiotics in use today. They eat hefty dosages each and every day and their gut microbiota abound with Lactobacillus and Bifidobacterium, just like PureBiotic™ contains.*61,62,63,64,65
Be sure to ensure that there is no ongoing noxious EMF exposure (WiFi, nearby Cell Towers, Smart Meters, etc.).78,79,80 Protect your patients with our line of proven EMF protection products from DefenderShield.®
SAME PRICE! – In our quest to best serve your patients to achieve a true regenerative lifestyle, we are not raising the price of our PureBiotic™ formula. May your practice enjoy greater success!
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
AThe gut microbiota refers to every resident microorganism, both microbes and macrobes such as multi-cellular parasite, living in a host, whether their ecological impact on the host is commensal, mutualistic, parasitic, or synergistic, and regardless of their size of taxonomy (parasitic bacteria, fungi, phages, viruses or worms).
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Dr. Iris Ayala, MD"I recommend MD Prescriptives to all my patients. They are non-GMO, vegan caps, with dosages higher than many other products, and are reasonably priced. These supplements are made with quality in mind."
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