Micronized DHEA

Micronized Dehydroepiandrosterone, better known as simply DHEA‚ should be understood as being the most abundant adrenal steroid hormone in the body. Our DHEA is made from natural wild yams. DHEA is the key basic material utilized by the adrenal glands for conversion into the all-important steroids: cortisol, testosterone, estrogens, and others. Just as importantly, the adrenals also secret DHEA directly into the blood stream, where similarly distal target cells throughout the body convert it into testosterone, estrogens and other hormones. The amount of each hormone that DHEA creates during the conversion process depends on an individual’s nutrient status‚ stress, age‚ and sex. Normally DHEA levels peak at around age 25‚ and then decline steadily to approximately 20% of normal levels by the Age of 70 (6). For those with additional stress, DHEA will decline more rapidly.

Therefore, because DHEA serves as a substrate to so many vital steroids essential to adapting to stress, approximately 50% or more of our most stressed patients reveals labs that show DHEA deficiency and are subsequently placed unto DHEA.

DHEA is a major adrenal hormone which supports the cortisol pathway and fundamental anti-inflammatory mechanisms in the body (12,13). Supplementing with DHEA can promote lean muscle mass, energy, stamina, sexual function, mood, immune function, circulatory health, joint health, hormone levels and more. Studies suggest that DHEA can aid and facilitate:

• a healthy aging process (1)
• hormone and adrenal balance (2)
• bone density (10-12)
• strength and lean muscle mass (4)
• sexual function (2,7,8)
• mood, memory (9) and well-being (5)
• immune function (1)
• cardiovascular health (3)
• anti-inflammatory processes (12,13)

DHEA: usage and safety precautions

DHEA-S blood levels should be measured and monitored to determine individual needs. The dosage increases in low adrenal states. The normal dose should be determined after discussion with your health-care provider. The average recommended dose is between 25 mg and 50 mg orally per day either divided in AM and noon or all in the AM.

Additional support of adrenal function should include 1) optimization of all hormones including thyroid; 2) nutrient measurement and correction of deficiencies; 3) optimizing detoxification and pH; 4) balancing the mind stressors; and 5) reducing the body stressors with oxygenation.

For further information on protocols for the adrenal glands please see

1. Video on MdPrescriptives , “ Tired of Being Tired”
2. Article “ Fatigue ! Adrenal Fatigue and What to DO ?”

Liposomal Formula

Liposomal formulas have increased absorbtion and bio-availability

Dehydroepiandrosterone, better known as simply DHEA‚ should be understood as being the most abundant adrenal steroid hormone in the body. Our DHEA is made from natural wild yams. DHEA is the key base material utilized by the adrenal glands for conversion into the all-important steroids: cortisol, testosterone, estrogens, and others. Just as importantly, the adrenals also secret DHEA directly into the blood stream, where similarly distal target cells throughout the body convert it into testosterone, estrogens and other hormones. The amount of each hormone that DHEA creates during the conversion process depends on an individual’s nutrient status‚ stress, age‚ and sex. Normally DHEA levels peak at around age 25‚ and then decline steadily to approximately 20% of normal levels by the Age of 70 (6). For those with additional stress, DHEA will decline more rapidly.

Therefore, because DHEA serves as a substrate to so many vital steroids essential to adapting to stress, approximately 50% or more of our most stressed patients reveals labs that show DHEA deficiency and are subsequently placed unto DHEA.

DHEA is a major adrenal hormone which supports the cortisol pathway and fundamental anti-inflammatory mechanisms in the body (12,13). Supplementing with DHEA can promote lean muscle mass, energy, stamina, sexual function, mood, immune function, circulatory health, joint health, hormone levels and more. Studies suggest that DHEA can aid and facilitate:

• a healthy aging process (1)
• hormone and adrenal balance (2)
• bone density (10-12)
• strength and lean muscle mass (4)
• sexual function (2,7,8)
• mood, memory (9) and well-being (5)
• immune function (1)
• cardiovascular health (3)
• anti-inflammatory processes (12,13)

DHEA: usage and safety precautions

DHEA-S blood levels should be measured and monitored to determine individual needs. The dosage increases in low adrenal states. The normal dose should be determined after discussion with your health-care provider. The average recommended dose is between 25 mg and 50 mg orally per day either divided in AM and noon or all in the AM.

Additional support of adrenal function should include 1) optimization of all hormones including thyroid; 2) nutrient measurement and correction of deficiencies; 3) optimizing detoxification and pH; 4) balancing the mind stressors; and 5) reducing the body stressors with oxygenation.

For further information on protocols for the adrenal glands please see

1. Video on MdPrescriptives , “ Tired of Being Tired”
2. Article “ Fatigue ! Adrenal Fatigue and What to DO ?”

RECOMMENDED DOSING:

1 spray is 5mg. Use 2-5 sprays under tongue in morning. Hold under tongue for 3 minutes or as long as possible.

Liver MD™ is one of our most comprehensive formulas because it covers broad-spectrum liver support. It is comprised of all non-GMO ingredients. Specifically, Liver MD™ promotes:

• Phase I liver detoxification (detoxication)*
• Phase II liver detoxication*
• Antioxidant protection*
• Glutathione production*
• Healthy Fat metabolism*

The liver uses an enzyme-based processing and transport system to eliminate toxins and their intermediates. This enzyme-based system primarily involves Phase I & II Conjugation Liver Detoxification (Detoxication). Phase I and II “conjugates” or attaches molecules to the toxins to better control, process and eliminate them. Initially conjugating a toxin can actually temporarily increase its toxicity, therefore antioxidants and toxin neutralizers are integral to this system. For example, Milk Thistle (Silybum marianum) and N-Acetyl Cysteine (NAC) are two superior neutralizers of many liver toxins passing through Phase I & II processing. This entire system is essential to the study of metabonomics, a critical science important to devising optimal methodologies to practice proficient regenerative medicine.*

Liver MD™ contains many other select nutrients and phytonutrients that promote liver regeneration and facilitate the liver in its full range of vital duties.*

Phase I Conjugation-Liver Detoxication utilizes a vast system of enzymes collectively termed the cytochrome P450 system. One key job of these enzymes is to snare onto toxins in order to more efficiently pass them on into Phase II Conjugation-Liver Detoxication.*

Liver MD™ contains key nutrients to aid Phase I Conjugation-Liver Detoxication.*

Phase I Conjugation-Liver Detoxification support and Healthy Fat Metabolism:

• B-Complex Vitamins provide powerful support for Phase I Conjugation-Liver Detoxication and proper liver fat metabolism. Biotin, Choline, and Inositol are three such B-complex vitamins critical to both Phase I Conjugation and healthy fat metabolism featured in Liver MD.^1,2,3*
• DIM (diindolylmethane) is a naturally occurring sulfur com-pound found in cruciferous vegetables, such as cabbage, broccoli or mustard greens. The DIM found in Liver MD™ has been enhanced for optimal absorption, and acts as a powerful promoter to help detoxify xenobiotics and toxic testosterone and estrogen intermetabolites.^4,5,6*

Phase II Conjugation-Liver Detoxication further processes these toxins into less toxic substances in such a manner that enables these toxins to be eliminated. Phase II Conjugation-Liver Detoxication involves six (6) pathways which may be optimized through select nutrients and phytonutrients.*

Liver MD™ helps support all six (6) Phase II Conjugation-Liver Detoxication Pathways, namely: Acetylation, Amino Acid Conjugation, Glucuronidation, Glutathione conjugation (Glutathionylation), Methylation, and Sulfation.*

Phase II Conjugation-Liver Detoxification support:

• Liver MD™ modulates and supports healthy levels of Acetylation by way of its ingredients: Turmeric (Curcuma longa), Alpha Lipoic Acid (ALA), and DIM.^7,8,9,10
• Liver MD™ modulates and supports healthy levels of Amino Acid Conjugation by way of its ingredients: L-Glycine, NAC and methionine.^11,12,13
• Liver MD™ is composed of ingredients which appear to modulate and support healthy levels of Glucuronidation including: Calcium glucarate, NAC, and DIM.^14,15,16 The glucuronidation process aids the body in detoxifying and eliminating fungal toxins, steroid hormones and automobile exhaust.*
• Liver MD™ ingredients promote healthy levels of Glutathione Conjugation. Specifically, ingredients are: NAC, Methionine, Glycine, ALA, Curcuma longa and Silybum marianum.¹⁷ ALA helps facilitate the recharging or renewal of select antioxidants, giving them added life.¹⁸ Turmeric exerts powerful antioxidant effects which help quench free radicals. Curcuma longa and methionine exert choleretic activity, which promotes the storage and release of bile (i.e., cholagogue effects) from the gallbladder.^19,20 Additionally Silybum marianum reduces liver injury from alcoholism, radiation exposure, toxic mushrooms (Amamita phalloides) and acetaminophen. Plus, emerging evidence suggests Curcuma longa and Silybum marianum also induce regenerative healing effects on the liver.^21,22*
• Liver MD™ ingredients promote healthy levels of Methylation. Specifically, L-Methionine is an amino acid which converts into SAMe, essential to the methylation pathway.²³ As a sulfur-containing amino acid, Methionine promotes both fat metabolism and glutathione production.²⁴*
• Liver MD™ ingredients promote healthy levels of Sulfation. For example, Sulfation is modulated and aided by both methionine as well as NAC.^25,26*

Warning: If pregnant, nursing, or planning on becoming pregnant, do not take this product.

Suggested Use: As a dietary supplement, take 1 capsule, twice daily, or as directed by your healthcare practitioner.

DIM® is a registered trademark of, and is licensed from, BioResponse, LLC, Boulder CO US Patent # 6,086,915

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

MD Prescriptives’™ NanoZeolite MD™ is made from a water suspension of natural food-grade zeolite which is sourced from uncontaminated clinoptilolite clay. More specifically, the primary bioactive ingredient found in NanoZeolite MD™ is composed of a silicate mineral complex featuring particle sizes with superior absorption high-surface energy over common food-grade zeolite products. The particle size range spans the upper nanometer to lower micrometer size ranges, which 'defines' the absorption powers (sorption capacity or biosorption performance) of the “micronized” zeolite particles as 'highly bioactive'.^1,2 These highly bioactive micronized zeolite particles efficiently promote removal of noxious body loads containing harmful chemicals (i.e., xenobiotic elimination), heavy metals (i.e., chelation), radionuclides (i.e., decorporation), offensive microbial secretions (i.e., exoprotein elimination), and even undesirable microbes (i.e., microbiota purification).^{3,4 *}

Safety and Efficacy

Zeolite is listed under the FDA’s G.R.A.S. list.⁵ Zeolite possesses powerful cation-exchange physics, making it ideal to grab onto (i.e., chelate) noxious cations.⁶ It has long been safely used as a feed additive for livestock to boost their health when confronting select health challenges.⁷ It is important that the clinoptilolite raw source material is tested for heavy metal contaminants prior to being manufactured into a nutraceutical product intended to induce chelation and decorporation in your patients.^8*

Promotes Detoxication

At the end of this discussion, we present two compelling unpublished clinical results conducted at a certified laboratory illustrating the amazing ability of the primary ingredient in NanoZeolite MD™ to induce highly cost-effective chelation and decorporation in your patients. You will see how this primary ingredient mobilizes deeply entrenched radionuclides and heavy metal stores when administered in the proper dosages.

What we do know from decades of remediation-related and livestock-related studies, is that food-grade zeolite offers great promise when used as a food supplement. Beyond 'food-grade' zeolite, highly bioactive micronized zeolite studies are just now emerging. Collectively these studies indicate that the primary ingredient in NanoZeolite MD™ may be safely used to help eliminate from your patients the following list of heavy metals:^*

1. Mercury,^9,10,11,12
2. Arsenic,^13,14
3. Lead (Pb),^15,16
4. Chromium (the toxic form - CrVI),¹⁷
5. Cadmium (Cd),^18,19,20,21
6. Nickel (Ni),²² as well as
7. Radionuclides (radioactive heavy metals).^23,24,25

Indications:^*

• Neurological disorders^26,27,28
• History of smoking²⁹
• History of regular alcohol consumption³⁰
• Metal dental fillings
• Exposure to heavy metals
• High fish ingestion
• Intestinal disorders, especially dysbiosis and diarrhea
• Antimicrobial resistance^31,32
• Microbial secretion detoxication
• Immunological associated inflammatory states

Supports a Healthy Microbiota

A large body of peer-reviewed evidence indicates the primary ingredient in NanoZeolite MD™ beneficially modulates the intestinal microbiota in at least three key ways.^33,34 First, the primary ingredient in NanoZeolite MD™ is known to promote the clearance of undesirable bacteria and viruses, plus effectively suppress proliferation of non-beneficial microbes such as Clostridia, E. coli, Klebsiella, Enterobacter, Salmonella and Proteobacteria. Secondly, the primary ingredient in NanoZeolite MD™ has been shown to promote the health imbuing rapid growth of two key beneficial probiotic genus, both Lactobacillus spp., as well as Bifidobacterium spp.^{35,36,37,38,39,40} And thirdly, the primary ingredient in NanoZeolite MD™ promotes pancreatic enzyme activity, while helping to eliminate intestinal toxemia, thereby favorably modulating the entire intestinal milieu.^41,42*

Supports Normal Cellular Growth

Natural food-grade zeolite is known to promote healthy modulation of receptor sites and genes associated with unhealthy cell growth. Natural food-grade zeolite accomplishes this while simultaneously reducing lipid peroxidation. The significance of this combined feat is that it promotes overall improvement in the health status and longevity in murines suffering from unhealthy cell growth.^43,44,45,46*

With the emergence of highly bioactive micronized zeolite, NanoZeolite MD™ may now become one of the most promising healthy cell growth modulators available to the clinical practice.*

Supports Healthy Immune System Functions

Many immune disorders center around excessive inflammation processes. As revealed in avian studies, one highly useful use of natural food-grade zeolite supplementation is its ability to help neutralize undesirable pro-inflammatory radicals and noxious microbe secretions such as mycotoxins, LPS and aflatoxin.^47,48,49,50 Interestingly, natural food-grade zeolite is an excellent chelator and eliminator of pro-inflammatory histamine.⁵¹ But beyond these lesser potent food-grade zeolite products, dietary supplementation with highly bioactive micronized zeolite offers the promise of an unexcelled means to: (A) improve and enhance several key immune functions, while (B) beneficially modulating inflammatory pathways.⁵² Specifically, the primary ingredient in NanoZeolite MD™ is known to: (1) increase the numbers of foci-regional macrophages and (2) promote their defensive respiratory burst capability in murines.^53,54*

Promotes Antioxidant Functions

Zeolite's superior antioxidant properties and beneficial influence on RedOx homeostasis are well-known. For example, zeolite significantly decreases ROS production and suppresses Nitric Oxide Synthase (NOS) while significantly increasing the bioactivity of glutathione peroxidase, catalase, S.O.D. and total antioxidant capacity.^55,56* Interestingly, one study suggests that to obtain best results, it may be wise to only administer highly bioactive micronized zeolite by itself, that is, not in direct combination with other anti-oxidants.⁵⁷

Zeolite Challenge Test (To Provoke Decorporation as well as Deep Tissue Chelation) - Two Case Outcomes*

1. A 37-year old male submitted a baseline urine specimen on June 09^th, 2016 to screen for heavy metals. Testing for a complete spectrum of heavy metals was undertaken by Access Medical Labs in Jupiter, FL. The lab determined there were only two heavy metals that were elevated out of twenty-one heavy metals tested. The results were as follows:

   • 3.95ug/g Niobium (Normal Range 0-0.5ug/g)
   • 0.5ug/g Thorium (Normal Range 0-0.1ug/g)

   Post-Testing - On June 13^th, 2016, after taking the primary ingredient of NanoZeolite MD™ at ten drops twice daily sublingual for 5 days, he again provided a urine sample for analysis to Access Medical Labs. Surprisingly, his heavy metal urine load (both in quantity as well as in spectrum of heavy metals detected) jumped significantly as excretion ensued (illustrating efficacious Mercury chelation as well as decorporation of Thorium) to the following values:

   • 12.56ug/g Bismuth (Normal Range 0-10ug/g)
   • 12.23ug/g Mercury (Normal Range 0-10ug/g)
   • 8.11ug/g Niobium (Normal Range 0-0.5ug/g)
   • 4721ug/g Rubidium (Normal Range 0-4000ug/g)
   • 1.3ug/g Thorium (Normal 0-0.1ug/g)
   • 1.4ug/g Tungsten (Normal Range 0-1ug/g)

2. A 57-year old male provided a urine sample on December 27, 2016 to Access Medical Labs. Out of Twenty-one heavy metals tested, none were shown to be above normal range. For example, at that time Mercury tested in the normal range at 3.02ug/g. After seven days of consuming the primary ingredient found in NanoZeolite MD™ at 10 drops twice daily, the following heavy metal was detected out of twenty-one tested:

   • 22.71ug/g Mercury (Normal Range 0-10ug/g)

In conclusion, the primary ingredient in NanoZeolite MD™ has been shown to promote heavy metal decorporation even when baseline urine samples detect no heavy metals present. At 10 drops taken sublingually twice daily for 5 to 7 days, the zeolite challenge test may unlock stores of heavy metals from their deep tissue resting places for urinary excretion.*

It may take up to 30 to 60 days at the dose of 10 drops twice daily to complete the decorporation process, depending upon the deep tissue saturation loads. However, prolonged supplementation with micronized zeolite is to be discouraged due to its eventual tendency to remove desirable macrominerals from the body.^58,59*

Daily dosages may be adjusted up or down to adjust to tolerance and vary the speed of elimination.*

Generally, 30 consecutive days of taking NanoZeolite MD™ sublingually is sufficient to maximize its healthful benefits. But repeated urinary screenings for heavy metals will typically confirm length of treatment required.*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

References

1. Hall JB, Dobrovolskaia MA, Patri AK, McNeil SE. Characterization of Nanoparticles for Therapeutics. Nanomedicine (Lond). 2007 Dec;2(6):789-803.
2. Horiba Particle Size Distribution Analyzer LA-950 V2; Project No.: 009-1144. ID# 201605261039963. Assay No.: E261/16. Hazen Refractive Index - Operator: A. Cavendor. Smallest zeolite particles detected were ≤877 nanometers (≤0.877µm) in diameter. Median particle size range ~10.80 micrometers. Hazen Research, Inc. May 5th, 2016.
3. Prasai TP, et al. Biochar, Bentonite and Zeolite Supplemented Feeding of Layer Chickens Alters Intestinal Microbiota and Reduces Campylobacter Load. PLoS One 2016 Apr 26;11(4):e0154061.
4. Hrenovic J, et al. Antimicrobial Activity of Commercial Zeolite A on Acinetobacter junii and Saccharomyces ceresvisiae. J Hazard Mater. 2010 Nov 15:183(1-3):655-63.
5. U.S. Food & Drug Administration. Database of Select Committee on GRAS Substances (SCOGS) Reviews. Report No.: 61; ID Code: 73987-94-7; CFR Section: 182.2727; Year – 1979.
6. Pabalan RT, Bertetti FP. Cation-exchange properties of natural zeolites. Nat. Zeolites 2001;45:453–518.
7. Papaioannou D., Katsoulos P. D., Panousis N., Karatzias H. The role of natural and synthetic zeolites as feed additives on the prevention and/or the treatment of certain farm animal diseases: a review. Microporous Mesoporous Mater. 2005;84:161–70.
8. Tao YF, Fang SY, Liu ZY, Wang Y, Zhu JH. Trapping the Lead Ion in Multi-Components Aqueous Solution by Natural Clinoptilolite. J Hazard Mater. 2010 Aug 15;180(1-3):282-8.
9. Cabanero AI, Madrid Y, Camara C. Effect of Animal Feed Enriched with Se and Clays on Hg Bioaccumulation in Chickens: in vivo Experimental Study. J Agric Food Chem. 2005 Mar 23;(53(6):2125-32.
10. Hou Y, Wu P, Zhu N. The Protective Effect of Clay Minerals Against Damage to Adsorbed DNA Induced by Cadmium and Mercury. Chemosphere. 2014 Jan;95:206-12.
11. Mier MV, Callejas RL, Gehr R, Cisneros BEJ. Heavy Metal Removal with Mexican Clinoptilolite: Multi-Component Ionic Exchange. Water Res. 2001 Feb;35(2):373-8.
12. Haidouti C. Inactivation of mercury in contaminated soils using natural zeolites. Sci Total Environ. 1997 Dec 3;208(1-2):105-9.
13. Bilgin Simsek E, Avci Tuna AO, Beker U. A Statistical Approach for Arsenic Adsorption onto Turkey Clinoptilolite. Environ Sci Pollut Res Int. 2015 Mar;22(5):3249-56.
14. Payne KB, Abdel-Fattah TM. Adsorption of Arsenate and Arsenite by Iron-Treated Activated Carbon and Zeolites: Effects of pH, Temperature, and Ionic Strength. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2005;40(4):723-49.
15. Delavarian M, Hassanvand A, Gharibzadeh S. Increasing Performance in Children with ADHD by Trapping Lead with a Nano-Zeolite. J Neuropsychiat Clin Neurosci. 2013;25(1):E23.
16. Orhan Y, Kocaoba S. Adsorption of Toxic Metals by Natural and Modified Clinoptilolite. Ann Chim. 2007 Aug;97(8):781-90.
17. Vaca Mier M, et al. Heavy Metal Removal with Mexican Clinoptilolite: Multi-Componnent Ionic Exchange. Water Res. 2001 Feb;35(2):373-8.
18. Faghir H, Hassanvand A, Gharibzadeh S. Removing Cadmium by Nano-Pore Zeolites to Decrease Aggressive Behavior, Stress, and Hyperactivity. J Neuropsychiat Clin Neurosci. 2013;25(2):E73.
19. Pond WG, Yen JT. Protection by Clinoptilolite or Zeolite NaA Against Cadmium-Induced Anemia in Growing Swine. Proc Soc Exp Biol Med. 1983 Jul;173(3):332-7.
20. Castalki P, Santona L, Enzo S, Melis P. Sorption Processes and XRD Analysis of a Natural Zeolite Exchange with Pb(2+), Cd(2+) and Zn(2+) Cations. J Hazard Mater. 2008 Aug 15;156(1-3)428-34.
21. Chi SL, et al. [Effect of Nano Zeolites on pH, CEC in Soil and Cd Fractions in Plant and Soil at Different Cadmium Levels]. Huan Jing Ke Xeu. 2017 Apr 8;38(4):1654-66.
22. Sprynskyy M, Buszewski B, Terzyk AP, Namiesnik J. Study of the Selection Mechanism of Heavy Metal (Pb2+, Cu2+, Ni2+, and Cd2+) Adsorption on Clinoptilolite. J Colliod Interface Sci. 2006 Dec 1;304(1):21-8.
23. Forberg S, Jones B, Westermark T. Can zeolites decrease the uptake and accelerate the excretion of radio-caesium in ruminants? Sci. Total Environ. 1989;79:37–41.
24. Mitrovic BM, et al. Comparative Study of (137(Cs Distribution in Broilers and Pheasants and Possibilities for Protection. Radiat Environ Biophys. 2012 Mar;51(1):79-84.
25. Mitrovic B, et al. AFCF and Clinoptilolite Use in Reduction of (137)Cs Deposition in Several Days’ Contamination Broiler Chicks. J Environ Radioact. 2007;95(2-3):171-7.
26. Schofield K. The Metal Neurotoxins: An Important Role in Current Human Neural Epidemics? Int J Environ Res Public Health. 2017 Dec 5;14(12). pii. E1511.
27. Faghir H, Hassanvand A, Gharibzadeh S. Removing Cadmium by Nano-Pore Zeolites to Decrease Aggressive Behavior, Stress, and Hyperactivity. J Neuropsychiat Clin Neurosci. 2013;25(2):E73.
28. Montinaro M, et al. Dietary Zeolite Supplement Reduces Oxidative Damage and Plaque Generation in the Brain of an Alzheimer’s Disease Mouse Model. Life Sci. 2013 May 20;92(17-19):903-10.
29. Dogliotti G, et al. Natural Zeolites Chabazite/Phillipsite/Analcime Increase Blood Levels of Antioxidants. J Clin Biochem Nutr. 2012 May;50(3):195-8.
30. Choi J, et al. Mercury Exposure in Association with Decreased of Liver Function in Adjults: A Longitudinal Study. J Prev Med Public Health. 2017 Nov;50(6):377-85.
31. Cheinia HY, Jacobs A. Antimicrobial Resistance, Heavy Metal Resistance and Integron Content in Bacteria Isolated from a South African Tilapia Aquaculture System. Dis Aquat Organ. 2017 Nov 21;126(3):199-209.
32. Yu Z, Gunn L, Wall P, Fanning S. Antimicrobial Resistance and Its Association with Tolerance to Heavy Metals in Agriculture Production. Food Microbiol. 2017 Jun;64:23-32.
33. Prasai TP, et al. Biochar, Bentonite and Zeolite Supplemented Feeding of Layer Chickens Alters Intestinal Microbiota and Reduces Campylobacter Load. PLoS One 2016 Apr 26;11(4):e0154061.
34. Bonna RJ, et al. Efficacy of Hydrated Sodium Calcium Aluminosilicate and Activated Charcoal in Reducing the Toxicity of Dietary Aflatoxin to Mink. Arch Environ Cotamin Toxicol. 1991 Apr;20(3):441-7.
35. Jung BG, et al. Dietary Aluminosilicate Supplement Enhances Immune Activity in Mice and Reinforces Clearance of Porcine Circovirus Type 2 in Experimentally Infected Pigs. Vet Microbiol. 2010 Jul 14;143(2-4):117-25.
36. Sabbioni A, et al. Modulation of the Bifidobacterial Communities of the Dog Microbiota by Zeolite. Front Microbiol. 2016;7:1491.
37. Song M, et al. Dietary Clays Alleviate Diarrhea of Weaned Pigs. J Anim Sci. 2012 Jan;90(1):345-60.
38. Subramaniam MD, Kim IH. Clays as Dietary Supplements for Swine: A Review. J Anim Sci Biotechnol. 2015 Aug 22;6(1):38.
39. Almeida JA, et al. Effects of Dietary Clays on Performance and Intestinal Mucus Barrier of Broiler Chicks Challanged with Salmonella enterica serovar Typhimurium and on Goblet Cell Function in vitro. Poult Sci. 2014 Apr;93(4):839-47.
40. Prasai TP, et al. Biochar, Bentonite and Zeolite Supplemented Feeding of Layer Chickens Alters Intestinal Microbiota and Reduces Campylobacter Load. PLoS One. 2016 Apr 26;11(4):e0154061.
41. Papaioannou D., Katsoulos P. D., Panousis N., Karatzias H. The role of natural and synthetic zeolites as feed additives on the prevention and/or the treatment of certain farm animal diseases: a review. Microporous Mesoporous Mater. 2005;84:161–70.
42. RodriguezFuentes G, Barrios MA, Iraizoz A, Perdomo I, Cedre B. Enterex: anti-diarrheic drug based on purified natural clinoptilolite. Zeolites 1997;19:441–8.
43. Pavelic K, et al. Natural Zeolite Clinoptilolite: New Adjuvant in Anticancer Therapy. J Mol Med. 2001;78(12):708-20.
44. Zarcovic N, et al. Anticancer and antioxidative effects of micronized zeolite clinoptilolite. Anticancer Res. 2003;23:1589–96.
45. Pavelic K, et al. Immunostimulatory effect of natural clinoptilolite as a possible mechanism of its antimetastatic ability. J Cancer Res Clin Oncol. 2002 Jan; 128(1):37-44.
46. Muck-Seler D, Pivac N. The Effect of Natural Clinoptilolite on the Serotonergic Receptors in the Brain of Mice with Mammary Carcinoma. Life Sci. 2003 Sep 5;73(16):2059-69.
47. Subramaniam MD, Kim IH. Clays as Dietary Supplements for Swine: A Review. J Anim Sci Biotechnol. 2015 Aug 22;6(1):38.
48. Wu QJ, Zhou YM, Wu YN, Zhang LL, Wang T. The Effects of Natural and Modified Clinoptilolite on Intestinal Barrier Functions and Immune Response to LPS in Broiler Chickens. Vet Immunol Immunopathol. 2013 May 15;153(1-2):70-6.
49. Visnja S, Sandra S, Tihomir B, Miroslav C, Tatjana M. Natural micronised clinoptilolite and clinoptilolite mixtures with Urtica dioicaL. extract as possible antioxidants. Food Technol Biotechnol. 2004;42(3):189–92.
50. Ortatatli M, Oguz H, Hatipoglu F, Karaman M. Evaluation of Pathological Changes in Broilers During Chronic Aflatoxin (50 and 100 ppb) and Clinoptilolite Exposure. Res Vet Sci. 2005 Feb;78(1):61-8.
51. Selvam T, Schwieger W, Dathe W. Histamine-Binding Capacities of Different Natural Zeolite: A Comparative Study. Environ Geochem Health. 2018 Jun 7. Doi: 10.1007/s10653-018-0129-5.
52. Ivkovic S, et al. Dietary Supplementation with the Tribomechanically Activated Zeolite Clinoptilolite in Immunodeficiency: Effects on the Immune System. Adv Ther. 2004 Mar-Apr;21(2):135-47.
53. Pavelic K, et al. Immunostimulatory Effect of Natural Zeolite Clinoptilolite as a Possible Mechanism of its Antimetastatic Ability. J Cancer Res Clin Oncol. 2002 Jan;128(1):37-44.
54. Fach E, et al. Analysis of the Biological and Chemical Reactivity of Zeolite-Based Aluminosilicate Fibers and Particlues. Environ Health Perspect. 2002 Nov;110(11):1087-96.
55. Laurino C, Palmieri B. Zeolite: “The Magic Stone”; Main Nutritional, Environmental, Experimental and Clinical Fields of Application. Nutr Hosp. 2015 Aug 1;32(2):573-81.
56. Wu Y, Wu Q, Zhou Y, Ahmad H, Wang T. Effects of Clinoptilolite on Growth Performance and Antioxidant Status in Broilers. Biol Trace Elem Res. 2013;155(2):228-35.
57. Omidi H, et al. Effects of Separate and Concurrent Supplementation of Nano-Sized Clinoptilolite and Nigella sativa on Oxidative Stress, Anti-oxidative Parameters and Body Weight in Rats with Type 2 Diabetes. Biomed Pharmacother. 2017 Dec;96:1335-40.
58. Shurson GC, Ku PK, Miller ER, Yokoyama MT. Effects of Zeolite A or Clinoptilolite in Diets of Growing Swine. J Anim Sci. 1984 Dec;59(6):1536-45.
59. Maisanaba S, et al. Toxicological Evaluation of Clay Minerals and Derived Nanocomposites: A Review. Environ Res. 2015 Apr;138:233-54.