* New Formula* PureBiotic 60 vcaps

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• We are very pleased to inform you we have produced a truly superior PureBiotic™ formula:

  MORE POTENT · LESS CAPSULES · MORE EFFECTIVE SPECIES · OPTIMIZE IMMUNITY · MORE REGENERATIVE IMPACT · SAME PRICE!

  Natural Full Spectrum Probiotic Blend Featuring 15 Probiotic Species Blended to Attain +28 Billion CFU per Serving

  Our new advanced PureBiotic™ formula optimally promotes quenching systemic inflammation, supporting superior immune system functions while facilitating better digestive functions than ever before. It remains the ideal choice for individuals with poor B-vitamin status, or for those production who recently have undergone antibiotic therapy. Our new formula maximally supports against gut microbial overgrowth (dysbiosis), constipation, diarrhea, and of course all gut conditions associated with gastro-intestinal inflammatory states.*

  Our New Specific Formula Advantages Now Includes 5 different Bifidobacterium:

  In general, Bifidobacteria are among the best colonizers of the human gut, especially with continued supplementation.^1,2 For perspective, Bifidobacteria are considered by some scholars to be more important to human gut health than contributions made by the Lactobacillus group.³ In breast-feeding infants, nearly 100% of probiotics colonizing the gut are Bifidobacteria, and climb to between 10¹⁰ to 10¹¹ CFU/gram of the breast-fed infants’ feces.⁴ Several of their pan-functions are to digest carbohydrates, manufacture B-complex vitamins, protect the gut from microbial invasion, reduce episodes of diarrhea, provide anti-mutagenic protection, and to build up and mature the immune system.⁵ By adulthood, Bifidobacteria will comprise only 5% to 10% of the total gut microbiota.*⁶

  Among the more prevalent Bifidobacterium residing in the human gut, from infancy into adulthood, are:*

  • Bifidobacterium bifidum,
  • B. breve,
  • B. longum,
  • B. animalis lactis and
  • B. lactis.

   

  1. Bifidobacterium bifidum – This specie has been extensively studied and has excellent ability to colonize the gut. Studies show it was among the top in persisting in the feces after over 3 weeks from when supplementation had ceased.*⁷

   2. B. breve - is also known to be immediately taken up and colonize the gut of new born infants.*⁸

   3. B. longum – As mentioned above, studies reveal that B. longum is one specie that is persistent in the gut into adulthood. It is considered to be the most prevalent in the human gut of all the Bifidobacteria.⁹ The specie possesses remarkable immune modulating effects throughout the life of the host. B. longum has good ability to colonize in the gut after supplementation has ceased.*¹⁰

   4. B. animalis lactis (VK2) – A study in combinations of select probiotics have shown that B. animalis lactis, when combined with L. acidophilus, can have up to 90% effectiveness in helping to eradicate H. pylori overgrowth.*¹¹

   5. B. lactis (BI-04) – This bacteria has an unusually high tolerance exposures to both high concentrations of oxygen and acid, leaving it very desirable to ferment milk products. B. lactis is most prevalent in human infants.*¹²

  Into adulthood, Bifidobacteria continue to promote a long list of health benefits, but decline in overall numbers by at least one order of magnitude. On the other hand, Lactobacillus colonization escalates and will attain approximately 10⁷ CFU/gram of feces.¹³ Both genus do not promote any kind of deleterious effects on the human being.*

  However, both Bifidobacteria and Lactobacillus are greatly outnumbered by a variety of other not-so-friendly (opportunistic or pathogenic) gut microbes by approximately 8 to 1. Overall the gut will contain from 100 to 400 Trillion microbes, or about 10X to 40X the number of total human cells in the body. So, the main job of both Bifidobacteria and Lactobacillus is to help reign-in rogue microbial actions which might otherwise turn against regions of human tissues.*

  Our New PureBiotic™ formula has 8 of the more studied Lactobacillus spp. Among the more common of Lactobacilli found in the human gut when consuming healthy diets are:*

  • Lactobacillus acidophilus
  • L. helveticus
  • L. planatrum
  • L. lactis
  • L. rhamnosus
  • L. salivarius
  • L. casei
  • L. bulgaricus
  • L. brevis

   

  6. Lactobacillus acidophilus (LA-14) – has the ability to temporarily populate deeply into the human gut. Interestingly, when it does so, the numbers of Lactobacilli in the gut soar after only 7 days of supplementation, but returns to their prior levels after 9 days after L. acidophilus supplementation is stopped. Therefore, this implies that to keep the numbers of lactobacilli up to optimal, L. acidophilus should be taken regularly with other lactobacilli.*¹⁴

   7. L. helveticus – the specie is renown for impacting the immune system in a multifunctional capacity in that both a variety of healthy bacteriocins as well as a fleet of bioactive peptides are secreted in abundance. In general, L. helveticus colonizes the human gut adequately to perform a plethora of health benefits.*¹⁵

   8. L. plantarum (LP-115) – is a specie well known to be able to pass through the upper intestinal tract to freely colonize the human gut. Several researchers have pointed out the L. plantarum acts similar to a living vaccine, providing ongoing immune modulation when and as needed.*¹⁶

  9. L. rhamnosus (LR-32) – is an excellent species to promote healthy modulation in hyperimmune state. For example, L. rhamnosus is known to balance and calm T-cell hyperactivity associated with hyperimmune states. More specifically, L. rhamnosus modulates the pre-cursor dentritic cells (DCs), which in turn calm the T-cell population contributing to the hyperimmune states.*¹⁷

  10. L. salivarius (LS-33) – this species is among the most populated in the human oral cavity. It protects against dental cavities and promotes healthy oral immunity.*¹⁸

• 11. L. casei (LC-11) – in a way similar to L. rhamnosus, L. casei calms skin contact hypersensitivity conditions, though beneficially modulating DCs.*¹⁹

  12. L. bulgaricus (LB-64) – species is a very important probiotic to enhance the digestion of cows milk. L. bulgaricus is known for abundantly producing highly bioactive proteases very helpful to aid digestion of cheeses and milk.*²⁰

  13. L. brevis – this specie is known for secreting a powerful immune modulating brevican which helps check unfriendly gut bacteria such as E. coli and especially Staphylococcus aureus.*²¹

  Finally, our new PureBiotic™ contains two remarkable probiotic species that have a synergistic interface, offering the host considerable defense against opportunistic microbes.*

  • Lactococcus lactis
  • Streptococcus thermophilus

   

  14. Lactococcus lactis – This species is very common to cultured milk products and acts as a nature preservative. Other features include its production of an abundance of immune modulating bacterocidins.*²²

  15. Streptococcus thermophilus (ATCC 5B5207) – Both Lactococcus lactis and Streptococcus thermophilus offer unique protections to their host by way of their secreted phages which interface and knock-down unfriendly bacterial phages which can cause severe gut inflammation.*²³

  MORE POTENT - Potency is not just about the CFU count (colony forming units), but also about the ability of the individual species to survive and pass through your patient’s stomach acid and take up residency (colonize) their 20+ feet of gut lining.*

  So, how can you tell if a high CFU count probiotic has effective species that do indeed pass on through to deliver alive probiotics into your patients’ entire digestive system? Simply put, it is about (A) lactic acid production (temporary gas!) and (B) achieving swifter successful outcomes.*

  For example, many patients will report that when first taking a more potent probiotic they experience gas initially, even cramps, which soon subside. This well-known temporary effect indicates that the all-important pH of the gut is being favorably modified.²⁴ Just imagine when baking soda comes into contact with vinegar, and you get the idea. pH is critical to gut health or ill-health, to enable patients to recover from long-term ingrained immune dis-regulation or not, as well as whether regenerative effects can be achieved in those patients or not.*

  Other patients will experience more significant detoxification events, such as mild headaches, temporary nausea or transient looser stools. More rarely your patients with long-term microbe stresses may experience generalized achiness, malaise and mild night sweats as probiotics correct the gut microbiota.*

  In patients long established on other probiotics, they too may notice more gas production or mild detoxification symptoms when taking a more potent and effective probiotic formula such as PureBiotic™.*

  Other indicators your patients are achieving better results with the new PureBiotic™ formula would be evidence of more efficacious outcomes, especially when managing your patients with the 5 Point Model System. Difficult cases will often bear evidence they are healing faster than before when dosing PureBiotic™ optimally.*

  Any one or more of these symptoms above is how you know that, in fact, you are giving them a more potent and effective probiotic product than the prior one they were given.*

  Because our new PureBiotic™ formula is more potent, it is important to more carefully manage patient experiences with their new inoculation of superior probiotics. Simply giving them a heads-up usually suffices, along with instructions to drink more water. When cleansing or detoxification reactions still occur, reducing dosage or skipping days in between dosage makes this adjustment period easier and more comfortable to accomplish in your patients. It is well worth the effort to do so, since better outcomes will soon become evident.*

  And as just mentioned above, a third indicator would be achieving regenerative healing, such as unscheduled healing (tough conditions thought by consensus to never heal, are in fact healed; for example, ingrained non-healing rectal wounds or fissures). Regenerative healing always involves enhanced detoxification, remodulation of gut microbiota, enhanced liver function, enhanced metabolic performance (i.e., better blood fat/ blood sugar regulation), enhanced immunity, and proper absorption and utilization of ‘regenerative nourishment’, all promoted by a superior probiotic formula.*²⁵

  More on this aspect as to how select probiotics such as those found in our new PureBiotic™ formula support regenerative healing is discussed below.*

  LESS CAPSULES - Survey after survey shows that patients prefer to take less capsules per day rather than more capsules of any given formula. Therefore, we designed and crafted PureBiotic™ to be more convenient for your patients by reducing our recommended serving dose down from 3 capsules daily to just 2 capsules daily. But to preserve all prior benefits, and yet boost even more benefits, we found we could only do this by: (1) retaining all prior probiotic members, (2) adding in three more health promoting species, and (3) increasing the potency per capsule. In fact, with your patients taking only 2 capsules daily now of our new formula they receive 1 billion more CFU count compared to before that when they were taking 3 capsules daily! In summary, with our carefully selected and coordinated combination of probiotic species, they now receive over 28 Billion CFU per serving from our new PureBiotic™ formula.*

  MORE EFFECTIVE SPECIES - With thousands of our patients having benefited from the original PureBiotic™ formula, we made sure to keep all of the original 12 individual probiotic species in our new formula.

  Additionally, we added three superior probiotic species (Lactobacillus helveticus and L. brevis, plus Bifidobacterium animalis lactis) to enhance immune functions, promote mental well-being, focus and calm, and enable regenerative effects to better initiate body-wide.^{26,27,28,29,30,31} Stay tuned for more info on these wonderful critters in follow-up emails.*

  But at this moment, in order to give you a clear clinical picture on the impact that PureBiotic™ is bound to have in your patients, it would be best to review the two-fold primary effects of probiotics – (A) gut microbiota^A reconditioning including gut pH modulation, and (B) immune optimization. Both these primary effects provide the foundation to the practice of regenerative medicine. There is the age-old dictum that death begins in the gut attributed to Hippocrates.³² But we say, regeneration must also begin in the gut. In fact, the word probiotics derives from “probios” which means, conducive to life, after Metchnikoff). So, what must we know to initiate from the deepest, most inner recesses of the body true and sustained regenerative healing? We must know and master the use of probiotics!*

  To understand the inner most workings of regenerative medicine stemming from the gut, we must begin with the basics. Feces are 90% water, 9% bacteria (good or bad) and only 1% fiber. So, optimal ingestion of water is key to optimize all probiotic supplementation outcome. Next, living fecal bacteria can only come from colonized gut microbes (the patients’ gut microbiota). If those colonized microbes have been producing harmful wastes and pH values along any section of the gut, the patient cannot properly heal themselves and is actually hastening their own ill-health.*³³

  PureBiotic™ places (right where it counts the most), 15 very powerful probiotics that both (A) out-compete those unhealthy microbes while correcting the gut pH,³⁴ as well as (B) optimize immune functions.³⁵ And remember, with such a potent probiotic formula, the diet must contain best nourishment for these health promoting species. Fiber therefore is quintessential to optimizing PureBiotic™ colonization into your patients’ gut. So, it is good to know that each capsule of PureBiotic™ contains a hefty dose of F.O.S., a preferred fiber happily eaten by PureBiotic™ microbes to enhance your patients’ gut colonization.³⁶ In this manner and in this manner only, can your patients’ gut microbiota and pH become optimized, and enhanced immunity initiate.*³⁷

  SYMPTOMS TO EXPECT - As a direct result, with such a more potent formula, you can expect to see greater impact on:

  (1) normalizing constipation quicker (e.g., more frequent bowel movements, easier bowel movements, less stinky bowel movements, etc.).*

  (2) correcting liver function, first confirmed by observing mild liver cleansing reactions, which typically may manifest as temporary mild nausea. This nausea will pass in a few days with persistent daily use of our new PureBiotic™ recommended dosage level.*

  (3) temporary increased gas production, which likewise will also will pass away and cease over the first week or two of supplementation.*

  We see about 15% to 20% of our patients experience one or more of these kind of cleansing symptoms when using PureBiotic™. You will too. When these signs and symptoms do arise, it is a clear indication of increased therapeusis instilled into our new formula. Just have the patient drink more water, eat a high fiber diet and temporarily reduce dosage as prudent until the patient is able to tolerate optimal dosage.*

  OPTIMIZE IMMUNITY – Select probiotics found within PureBiotic™ have been carefully selected to stimulate beneficial immune responses by the white blood cells. Three precise mechanisms stand out as to how probiotics enhance immune functions. In addition to probiotics’ secretions that target direct intervention against noxious members of the gut microbiota,³⁸ since 2000, elegant studies have decisively demonstrated that probiotics induce both innate and adaptive immune responses. Enhanced, induced innate immune responses would include probiotics’ ability to both upregulate immune cells’ respiratory burst and Phagocytic Index.³⁹ Enhanced, induced adaptive immune responses would include probiotics’ ability to upregulate ‘balanced’ immune cell cytokine production and chemokine dynamics,⁴⁰ as well as to induce immune tissues to secrete protective anti-microbe agents and/or activate and launch armies of fresh immune cells.^{41,42,43,44,45} Together, these mechanism bring about a modulation of the entire body’s gut microbiota which lessens deleterious members and increases symbiotic members.*

  REGENERATIVE IMPACT – Over time, this symbiosis between colonized probiotics triggering enhanced performance by immune cells, engages regenerative activities that impact the entire body. But one may ask how does this actually come about? Recall that the intestinal tract from mouth to anus is considered the exterior part of the intestines, since it is in continuous contact with the external environment. This is termed the brush border. And recall that as food passes through this brush border to the other side, this other side (the interior intestinal region) is completely inundated, coated if you will, with approximately 70% of all immune cells by quantity. This enormous number of immune cells numbering in the high billions are voraciously awaiting to engulf regenerative effectors (food factors rich in growth factors), to speed and enhance their primary job of repair and systemic regeneration.*⁴⁶

  The carcasses (antigens) and immunomodulating actions and secretions of the beneficial probiotics, are taken up by the awaiting immune cells stationed along the 20+ feet of the interior/internal intestinal region.⁴⁷ For example, the probiotic antigens when engulfed by the awaiting immune cells trigger a regenerative healing sequence, starting with promoting secretion of cytokines by the immune cells themselves, due to the probiotics’ immune-stimulating antigenic nature.^48,49,50 The more these immune cells feast on the probiotic carcasses, the greater their production of beneficial cytokines. Cytokines are also known as growth factors, and for good reason. Growth factors are the core foundation to regenerative healing in the body.  Other growth factors secreted by probiotics that are not strictly cytokines, but yet induce rapid healing, are L-lactic acid and butyric acid. Growth factors awaken adult stem cells (e.g., osteochondroprogenitor cells).⁵¹ If the diet is also adhering to the principles of the 5 Point Model System of regenerative medicine, additional growth factors from the diet join these white blood cells own production of growth factors of probiotic etiology,^52,53 and the stage is set for high-gain targeted tissue regeneration.*^54,55,56,57

  Put another way, gut-associated cells feasting continually on:

  (A) adequate levels of incoming dietary raw embryonic foods, such as blue-green algae⁵⁸, mushrooms, bee pollen, freeze-dried glandular meats, etc., (collectively termed colloidal Regenerative Factors – cRFs)⁵⁹ PLUS

  (B) on growth factor stimulating probiotic secretions and carcasses⁶⁰…

  … induce target tissue specificity into immune cells to (i) heighten repair to optimal, (ii) reduce all biomarkers to aging (e.g., phase angle index, etc.) and (iii) mimic the core regenerative mechanisms of the long-living. More on this later.*

  THERAPEUTIC INDEX – The long-living people from around the world are in fact the original source of our probiotics in use today. They eat hefty dosages each and every day and their gut microbiota abound with Lactobacillus and Bifidobacterium, just like PureBiotic™ contains.*^{61,62,63,64,65}

  1. Maximum Therapeutic Index Range (e.g., for patients with significant to severe immune disfunctions) - Titrating up slowly, starting with 1 capsule with meals for three days to determine tolerance, then raising dosage up to 1 capsule hourly (12 daily) for 3 months can bring about restored immunity. It is imperative that the 5 Point Model System of regenerative medicine is in place, which stresses detoxification procedures to lessen Jarisch-Herxheimer events associated with remodulating the patients’ gut microbiota.*
  2. Ideal Therapeutic Index Range - We recommend everyone desiring to achieve living a regenerative lifestyle to take 2 capsules PureBiotic™ daily, one with breakfast and one with dinner indefinitely.*
  3. Adequate Therapeutic Index Range - For maintenance and when on a tight budget, simply take 1 capsule with breakfast.*
  4. During antibiotic therapy - We recommend taking 2 capsules PureBiotic™ at bedtime or 3 hours after the last antibiotic dose of the day.*⁶⁶
  5. After completing a course of antibiotic therapy – We recommend taking 2 capsules per meal for one bottle may be wisest. Thereafter, reduce dosage to one capsule with breakfast and one with dinner.*⁶⁷
  6. For short-term intestinal disturbances – For those unexpected events such as mild food poisoning, mild diarrhea, intestinal griping, nausea, etc., we recommend taking 1 capsule every two hours until symptoms disappear.*^68,69
  7. For long-term intestinal disturbances – For ingrained gut events such as: (a) polyps, (b) irritable gut contractions, (c) inflamed gut lining, (d) entrenched dysbiosis, (e) chronic constipation, (f) fissures, (g) hemorrhoids, (h) liver congestion or inflammation, (i) pancreatic inflammation, (j) stomach inflammation, (k) indigestion, (l) heartburn, (m) esophageal inflammation, (n) throat inflammation, (o) dental inflammation, (p) dermal inflammation or dysbiosis, (q) joint inflammation, (r) respiratory inflammation and congestion, (s) immune dysregulation, (t) metabolic dysregulation, (u) aberrant cell growth, (v) blood sugar regulation, blood lipids regulation, (w) malabsorption, etc. … taking 1 to 2 with each meal will promote and aid optimal outcomes when administered within the 5 Point Model System of regenerative medicine.*^{70,71,72,73,74,75,76,77}
  8. Minimal Therapeutic Index Range – We recommend taking at least 1 capsule PureBiotic™ every three days to minimally recharge your patients’ gut flora, so long as high-fiber diets are in place with good water intake.*

  Be sure to ensure that there is no ongoing noxious EMF exposure (WiFi, nearby Cell Towers, Smart Meters, etc.).^78,79,80 Protect your patients with our line of proven EMF protection products from DefenderShield.®

  SAME PRICE! – In our quest to best serve your patients to achieve a true regenerative lifestyle, we are not raising the price of our PureBiotic™ formula. May your practice enjoy greater success!

   

  *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

• REFERENCES

  ^AThe gut microbiota refers to every resident microorganism, both microbes and macrobes such as multi-cellular parasite, living in a host, whether their ecological impact on the host is commensal, mutualistic, parasitic, or synergistic, and regardless of their size of taxonomy (parasitic bacteria, fungi, phages, viruses or worms).

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  41.  Ayabe T, Satchell DP, Wilson CL, Parks WC, Selsted ME, Ouellette AJ. Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria. Nat Immunol. 2000 Aug; 1(2):113-8.
  42.  Stappenbeck TS, Hooper LV, Gordon JI. Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells. Proc Natl Acad Sci U S A. 2002 Nov 26; 99(24):15451-5.
  43.  Weaver CT, Harrington LE, Mangan PR, Gavrieli M, Murphy KM. Review - Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity. 2006 Jun; 24(6):677-88.
  44.  Cash HL, Whitham CV, Behrendt CL, Hooper LV. Symbiotic bacteria direct expression of an intestinal bactericidal lectin. Science. 2006 Aug 25; 313(5790):1126-30.
  45.  Macpherson AJ, Gatto D, Sainsbury E, Harriman GR, Hengartner H, Zinkernagel RM. A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria. Science. 2000 Jun 23; 288(5474):2222-6.
  46.  See – Integrative Regenerative Medicine: Colloidal Regenerative Factors (cRFs) and The Regeneration Effect è  https://www.amazon.com/Integrative-Regenerative-Medicine-Colloidal-Regeneration-ebook/dp/B01EEPYJRQ/ref=sr_1_1?keywords=John+Apsley&qid=1553438206&s=hpc&sr=8-1
  47.  Mammalian intestine contains a large diversity of commensal microbiota, which is far more than the number of host cells. Probiotics play an insecure and protective role against the colonization of intestinal pathogenic microbes and increase mucosal integrity by stimulating epithelial cells. Probiotics have innate capabilities in many ways, including receptor antagonism, receptor expression, binding and expression of adapter proteins, expression of negative regulatory signal molecules, induction of microRNAs, endotoxin tolerance, and ultimately secretion of immunomodulatory proteins, lipids, and metabolites to modulate the immune system. Probiotic bacteria can affect homeostasis, inflammation, and immunopathology through direct or indirect effects on signaling pathways as immunosuppressant or activators. Probiotics suppress inflammation by inhibiting various signaling pathways such as the nuclear factor-κB (NF-κβ) pathway, possibly related to alterations in mitogen-activated protein kinases and pattern recognition receptors pathways. Probiotics can also inhibit the binding of lipopolysaccharides to the CD14 receptor, thereby reducing the overall activation of NF-κβ and producing proinflammatory cytokines. Some effects of modulation by probiotics include cytokine production by epithelial cells, increased mucin secretion, increased activity of phagocytosis, and activation of T and natural killer T cells, stimulation of immunoglobulin A production and decreased T cell proliferation. Intestinal microbiota has a major impact on the systemic immune system. Specific microbiota controls the differentiation of cells in lamina propria, in which Th17 cells secrete interleukin 17. The presence of Th17 and Treg cells in the small intestine is associated with intestinal microbiota, with the preferential Treg differentiation and the absence of Th17 cells, possibly reflecting alterations in the lamina propria cytokines and the intestinal gut microbiota. Abstract to: Yousefi B, et al. Probiotics Importance and Their Immunomodulatory Properties. J Cell Physiol. 2019 Jun;234(6):8008-18.
  48.  Patel R, DuPont HL. New Approaches for Bacteriotherapy: Prebiotics, New-Generation Probiotics, and Synbiotics. Clin Infect Dis. 2015 May 15;60(Suppl 2):S108-S121.
  49.  Yousefi B, et al. Probiotics Importance and Their Immunomodulatory Properties. J Cell Physiol. 2019 Jun;234(6):8008-18.
  50.  Llewellyn A, Foey A. Probiotic Modulation of Innate Cell Pathogen Sensing and Signaling Events. Nutrients. 2017 Oct; 9(10): 1156. 
  51.  Houschyar KS, et al. Wnt Pathway in Bone Repair and Regeneration - What Do We Know So Far. Front Cell Dev Biol. 2019 Jan 7;6:170.
  52.  Smelt MJ, et al. Probiotics can generate FoxP3 T-cell responses in the small intestine and simultaneously inducing CD4 and CD8 T cell activation in the large intestine. PLoS One. 2013 Jul 4;8(7):e68952.
  53.  Ghoneum M, Felo N, Agrawal S, Agrawal A. A novel kefir product (PFT) activates dendritic cells to induce CD4+T and CD8+T cell responses in vitro. Int J Immunopathol Pharmacol. 2015 Dec;28(4):488-96.
  54.  Lukic J, et al. Probiotics or pro-healers: the role of beneficial bacteria in tissue repair. Wound Repair Regen. 2017 Nov;25(6):912-922. 
  55.  Oryan A, Alemzadeh E, Eskandari MH. Kefir Accelerates Burn Wound Healing Through Inducing Fibroblast Cell Migration In Vitro and Modulating the Expression of IL-1ß, TGF-ß1, and bFGF Genes In Vivo. Probiotics Antimicrob Proteins. 2018 Jun 8. doi: 10.1007/s12602-018-9435-6. [Epub ahead of print]
  56.  Athiyyah AF, et al. Lactobacillus plantarum IS-10506 activates intestinal stem cells in a rodent model. Benef Microbes. 2018 Sep 18;9(5):755-60. 
  57.  Liu J, et al. Antibiotic-Induced Dysbiosis of Gut Microbiota Impairs Corneal Nerve Regeneration by Affecting CCR2-Negative Macrophage Distribution. Am J Pathol. 2018 Dec;188(12):2786-99.
  58.  See - The Regeneration Effect: A Professional Treatise on Self-Healing by Dr. John Apsley è https://www.amazon.com/Regeneration-Effect-Professional-Treatise-Healing/dp/B0029ZN6LY/ref=sr_1_5?keywords=John+Apsley&qid=1553438206&s=hpc&sr=8-5
  59.  See – Integrative Regenerative Medicine: Colloidal Regenerative Factors (cRFs) and The Regeneration Effect è  https://www.amazon.com/Integrative-Regenerative-Medicine-Colloidal-Regeneration-ebook/dp/B01EEPYJRQ/ref=sr_1_1?keywords=John+Apsley&qid=1553438206&s=hpc&sr=8-1
  60.  Tyagi AM, et al.The Microbial Metabolite Butyrate Stimulates Bone Formation via T Regulatory Cell-Mediated Regulation of WNT10B Expression. Immunity. 2018 Dec 18;49(6):1116-1131.e7.
  61.  Gu RX, Yang ZQ, Li ZH, Chen SL, Luo ZL. Probiotic properties of lactic acid bacteria isolated from stool samples of longevous people in regions of Hotan, Xinjiang and Bama, Guangxi, China. Anaerobe. 2008 Dec;14(6):313-7.
  62.  Biagi E, et al. Gut microbiota and extreme longevity. Curr Biol. 2016;26:1480-5.
  63.  Kong F, Deng F, Li Y, Zhao J. Identification of gut microbiome signatures associated with longevity provides a promising modulation target for healthy aging. Gut Microbes. 2018 Aug 24:1-6.
  64.  Santoro A, et al. Gut microbiota changes in the extreme decades of human life: a focus on centenarians. Cell Mol Life Sci. 2018 Jan;75(1):129-148.
  65.  Deng F, Li Y, Zhao J. The gut microbiome of healthy long-living people. Aging (Albany NY). 2019 Jan 15;11(2):289-290.
  66.  Allen SJ, et al. A high-dose preparation of lactobacilli and bifidobacteria in the prevention of antibiotic-associated and Clostridium difficile diarrhoea in older people admitted to hospital: a multicentre, randomised, double-blind, placebo-controlled, parallel arm trial (PLACIDE). Health Technol Assess. 2013 Dec;17(57):1-140.
  67.  Allen SJ, et al. A high-dose preparation of lactobacilli and bifidobacteria in the prevention of antibiotic-associated and Clostridium difficile diarrhoea in older people admitted to hospital: a multicentre, randomised, double-blind, placebo-controlled, parallel arm trial (PLACIDE). Health Technol Assess. 2013 Dec;17(57):1-140.
  68.  Roussel C, Sivignon A, de Wiele TV, Blanquet-Diot S. Foodborne enterotoxigenic Escherichia coli: from gut pathogenesis to new preventive strategies involving probiotics. Future Microbiol. 2017 Jan;12:73-93.
  69.  Ruiz MJ, Colello R, Padola NL, Etcheverría AI. [Inhibitory capacity of Lactobacillus spp. against pathogens involved in foodborne diseases]. Rev Argent Microbiol. 2017 Apr - Jun;49(2):174-177.
  70.  Plaza-Diaz J, Ruiz-Ojeda FJ, Gil-Campos M, Gil A. Mechanisms of Action of Probiotics. Adv Nutr. 2019 Jan 1;10(suppl_1):S49-S66.
  71.  Im AR, Lee B, Kang DJ, Chae S. Skin Moisturizing and Antiphotodamage Effects of Tyndallized Lactobacillus acidophilus IDCC 3302. J Med Food. 2018 Oct;21(10):1016-1023.
  72.  Slattery J, MacFabe DF, Frye RE. The Significance of the Enteric Microbiome on the Development of Childhood Disease: A Review of Prebiotic and Probiotic Therapies in Disorders of Childhood. Clin Med Insights Pediatr. 2016; 10: 91–107.
  73.  Mallappa RH, et al. Management of metabolic syndrome through probiotic and prebiotic interventions. Indian J Endocrinol Metab. 2012 Jan-Feb; 16(1): 20–27.
  74.  Panebianco C, Andriulli A, Pazienza V. Pharmacomicrobiomics: exploiting the drug-microbiota interactions in anticancer therapies. Microbiome. 2018; 6: 92. Published online 2018 May 22.
  75.  Yao K, Zeng L, He Q, Wang W, Lei J, Zou X. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research. 2017 Jun 22; 23: 3044-3053.
  76.  Nazir Y, Hussain SA, Hamid AA, Song Y. Probiotics and Their Potential Preventive and Therapeutic Role for Cancer, High Serum Cholesterol, and Allergic and HIV Diseases. Biomed Res Int. 2018; 2018: 3428437.
  77. Liu Y, Alookaran JJ, Rhoads JM. Probiotics in Autoimmune and Inflammatory Disorders. Nutrients. 2018 Oct; 10(10): 1537.
  78.  Crabtree DPE, Herrera BJ, Kang S. The Response of Human Bacteria to Static Magnetic Field and Radiofrequency Electromagnetic Field. J Microbiol. 2017 Oct;55(10):809-15.
  79.  Vasistha S, Garg A. Effect of Electromagnetic Radiation on Lactobacillus Species. J Chem Pharmaceut Res. 2016;8(7):123-6. See: http://www.jocpr.com/articles/effect-of-electromagnetic-radiation-on-lactobacillus-species.pdf
  80.  Gray JM, Rasanayagam S, Engel C, Rizzo J. State of the Evidence 2017: An Update on the Connection Between Breast Cancer and the Environment Environ Health. 2017;16:94.

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Liver MD™

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• Liver MD™ is one of our most comprehensive formulas because it covers broad-spectrum liver support. It is comprised of all non-GMO ingredients. Specifically, Liver MD™ promotes:

  • Phase I liver detoxification (detoxication)*
  • Phase II liver detoxication*
  • Antioxidant protection*
  • Glutathione production*
  • Healthy Fat metabolism*

  The liver uses an enzyme-based processing and transport system to eliminate toxins and their intermediates. This enzyme-based system primarily involves Phase I & II Conjugation Liver Detoxification (Detoxication). Phase I and II “conjugates” or attaches molecules to the toxins to better control, process and eliminate them. Initially conjugating a toxin can actually temporarily increase its toxicity, therefore antioxidants and toxin neutralizers are integral to this system. For example, Milk Thistle (Silybum marianum) and N-Acetyl Cysteine (NAC) are two superior neutralizers of many liver toxins passing through Phase I & II processing. This entire system is essential to the study of metabonomics, a critical science important to devising optimal methodologies to practice proficient regenerative medicine.*

  Liver MD™ contains many other select nutrients and phytonutrients that promote liver regeneration and facilitate the liver in its full range of vital duties.*

  Phase I Conjugation-Liver Detoxication utilizes a vast system of enzymes collectively termed the cytochrome P450 system. One key job of these enzymes is to snare onto toxins in order to more efficiently pass them on into Phase II Conjugation-Liver Detoxication.*

  Liver MD™ contains key nutrients to aid Phase I Conjugation-Liver Detoxication.*

  Phase I Conjugation-Liver Detoxification support and Healthy Fat Metabolism:

  • B-Complex Vitamins provide powerful support for Phase I Conjugation-Liver Detoxication and proper liver fat metabolism. Biotin, Choline, and Inositol are three such B-complex vitamins critical to both Phase I Conjugation and healthy fat metabolism featured in Liver MD.^1,2,3*
  • DIM (diindolylmethane) is a naturally occurring sulfur com-pound found in cruciferous vegetables, such as cabbage, broccoli or mustard greens. The DIM found in Liver MD™ has been enhanced for optimal absorption, and acts as a powerful promoter to help detoxify xenobiotics and toxic testosterone and estrogen intermetabolites.^4,5,6*

  Phase II Conjugation-Liver Detoxication further processes these toxins into less toxic substances in such a manner that enables these toxins to be eliminated. Phase II Conjugation-Liver Detoxication involves six (6) pathways which may be optimized through select nutrients and phytonutrients.*

  Liver MD™ helps support all six (6) Phase II Conjugation-Liver Detoxication Pathways, namely: Acetylation, Amino Acid Conjugation, Glucuronidation, Glutathione conjugation (Glutathionylation), Methylation, and Sulfation.*

  Phase II Conjugation-Liver Detoxification support:

  • Liver MD™ modulates and supports healthy levels of Acetylation by way of its ingredients: Turmeric (Curcuma longa), Alpha Lipoic Acid (ALA), and DIM.^7,8,9,10
  • Liver MD™ modulates and supports healthy levels of Amino Acid Conjugation by way of its ingredients: L-Glycine, NAC and methionine.^11,12,13
  • Liver MD™ is composed of ingredients which appear to modulate and support healthy levels of Glucuronidation including: Calcium glucarate, NAC, and DIM.^14,15,16 The glucuronidation process aids the body in detoxifying and eliminating fungal toxins, steroid hormones and automobile exhaust.*
  • Liver MD™ ingredients promote healthy levels of Glutathione Conjugation. Specifically, ingredients are: NAC, Methionine, Glycine, ALA, Curcuma longa and Silybum marianum.¹⁷ ALA helps facilitate the recharging or renewal of select antioxidants, giving them added life.¹⁸ Turmeric exerts powerful antioxidant effects which help quench free radicals. Curcuma longa and methionine exert choleretic activity, which promotes the storage and release of bile (i.e., cholagogue effects) from the gallbladder.^19,20 Additionally Silybum marianum reduces liver injury from alcoholism, radiation exposure, toxic mushrooms (Amamita phalloides) and acetaminophen. Plus, emerging evidence suggests Curcuma longa and Silybum marianum also induce regenerative healing effects on the liver.^21,22*
  • Liver MD™ ingredients promote healthy levels of Methylation. Specifically, L-Methionine is an amino acid which converts into SAMe, essential to the methylation pathway.²³ As a sulfur-containing amino acid, Methionine promotes both fat metabolism and glutathione production.²⁴*
  • Liver MD™ ingredients promote healthy levels of Sulfation. For example, Sulfation is modulated and aided by both methionine as well as NAC.^25,26*

  Warning: If pregnant, nursing, or planning on becoming pregnant, do not take this product.

  Suggested Use: As a dietary supplement, take 1 capsule, twice daily, or as directed by your healthcare practitioner.

  DIM® is a registered trademark of, and is licensed from, BioResponse, LLC, Boulder CO US Patent # 6,086,915

  *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

• REFERENCES

  1. Aguilera-Mendez A, Fernandez-Mejia C. The Hypotriglyceridemic Effect of Biotin Supplementation Involves Increased Levels of cGMP and AMPK Activation. Biofactors. 2012 Sep-Oct;38(5):387-94.
  2. Schenkel LC, et al. Choline Supplementation Restores Substrate Balance and Alleviates Complications of Pcyt2 Deficiency. J Nutr Biochem. 2015 Nov;26(11):1221-34.
  3. Zempleni J, Wijeratne SSK, Hassan YI. Biotin. Biofactors. 2009 Jan-Feb;35(1):36-46.
  4. Banerjee S, et al. Attenuation of Multi-targeted Proliferation-linked Signaling by 3,3’-diindolylmethane (DIM): From Bench to Clinic. Metat Res. 2011 Jul-Oct;728(1-2):47-66.
  5. Le HT, et al. Plant-derived 3,3’-Diindolylmethane is a Strong Androgen Antagonist in Human Prostate Cancer Cells. J Biol Chem. 2003 Jun 6;278(23):21136-45.
  6. Smith S, et al. 3,3’-Diindolylymethane and Genistein Decrease the Adverse Effects of Estrogen in LNCaP and PC-3 Prostate Cancer Cells. J Nutri. 2008 Dec;138(12):2379-85.
  7. Yan X, et al. Inhibition of Histone Acetylation by Curcumin Reduces Alcohol-Induced Fetal Cardiac Apoptosis. J Biomed Sci. 2017 Jan 5;24(1):1.
  8. Kalea AZ, Drosatos K, Buxton JL. Nutriepigenetics and Cardiovascular Disease. Curr Opin Clin Nutri Metab Care. 2018 Jul;21(4):252-9.
  9. Valdecantos MP, et al. Lipoic acid improves mitochondrial function in nonalcoholic steatosis through the stimulation of sirtuin 1 and sirtuin 3. Obesity (Silver Spring). 2012 Oct;20(10):1974-83.
  10. Beaver LM, et al. 3m3’-Diindolylmethane, But Not Indole-3-Carbinol, Inhibits Histone Deacetylase Activity in Prostate Cancer Cells. Toxicol Appl Pharmacol. 2012 Sep 15;263(3):345-51.
  11. Van der Sluis R, et al. New Insights into the Catalytic Mechanism of Human Glycine N-Acyltransferase. J Biochem Mol Toxicol. 2017 Nov;31(11).
  12. Badenhorst CP, van der Sluis R, Erasmus E, van Dijk AA. Glycine conjugation: importance in metabolism, the role of glycine N-acyltransferase, and factors that influence interindividual variation.

      Expert Opin Drug Metab Toxicol. 2013 Sep; 9(9):1139-53.

  13. Lin S, et al. Redox-Based Reagents for Chemoselective Methionine Bioconjugation. Science. 2017 Feb 10;355(6325):597-602.
  14. Oredipe OA, Barth RF, Dwivedi C, Webb TE. Dietary Glucarate-Mediated Inhibition of Initiation of Diethylnitrosamine-Induced Hepatocarcinogenesis. Toxicology. 1992 Sep;74(2-3):209-22.
  15. Dean B, et al. Glucuronidation, Oxidative Metabolism, and Bioactivation of Enterolactone in Rhesus Monkeys. Arch Biochem Biophys 2004 Sep 15;429(2):244-51.
  16. Pantuck EJ, et al. Effect of Brussels Sprouts and Cabbage on Drug Conjugation. Clin Pharmacol Ther. 1084 Feb;35(2):161-9.
  17. Bijak M. Silybin, a Major Bioactive Component of Milk Thistle (Silybum marianum L. Gaent.)-Chemistry, Bioavailability, and Metabolism. Molecules. 2017 Nov 10;22(11): pii: E1942.
  18. Wnag Y, Wang L, Zhu X, Wang D, Li X. Choleretic Activity of Turmeric and its Active Ingredients. J Food Sci. 2016 Jul;81(7):H1800-6.
  19. Hawkins WB, Hanson PC. Bile Salt Metabolism as Influenced by Pure Amino Acids and Casein Digests. J Exp Med. 1949;90(5):461-73.
  20. Gozeneli O, et al. Effects of Thymoquinone and Curcumin on the Regeneration of Rat Livers Subject to 70% Hepatectomy. Acta Cir Bras. 2018 Feb;33(2):110-6.
  21. Abenavoli L, Capasso R, Milic N, Capasso F. Milk Thistle in Liver Disease: Past, Present, Future. Phytother Res. 2010 Oct;24(10):1423-32.
  22. Pascale RM, Feo CF, Calvisi DF, Feo F. Deregulation of Methionine Metabolism as Determinant of Progression and Prognosis of Hepatocellular Carcinoma. Transl Gastroenterol Hepatol. 2018 Jun 29;3:36.
  23. Ruan T, Li L, Lyu Y, Luo Q, Wu B. Effect of Methionine Deficiency on Oxidative Stress and Apoptosis in the Small Intestines of Broilers. Acta Vet Hung. 2018 Mar;66(1):52-65.
  24. Milkiewicz P, Roma MG, Cardenas R, Mills CO, Elias E, Coleman R. Effect of tauroursodeoxycholate and S-adenosyl-L-methionine on 17beta-estradiol glucuronide-induced cholestasis. J Hepatol. 2001 Feb;34(2):184-91.
  25. Monti L, et al. N-Acetylcysteine Treatment Ameliorates the Skeletal Phenotype of a Mouse Model of Diastrophic Dysplasia. Hum Mol Genet. 2015 Oct 1;24(19):5570-80.

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MetabolicMD

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• Description
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• Facilitates Rapid Normalizing of Blood Fat and Blood Sugar Levels / Promotes An Optimal Metabolism / Targets Reversing Key Aging Indicators* 

  We are extremely excited to announce that both Cholest-X™ and Gluco-X™ are now reformulated into one single unprecedented product - Metabolic MD™. Metabolic MD™ is a truly historic, highly bioavailable, first-to-market liposomal purified-berberine formula. Elegant studies confirm that Metabolic MD's™ energizing ingredients swiftly help normalize ACE, AGEs, blood fat and blood sugar levels, while cost-effectively inducing healthy weight-loss without jitteriness.*

  Metabolic MD™ is an evidence-based, synergistic, comprehensive formulation* designed to:

  • Promote rewarding and consistent clinical outcomes in complex metabolic “group” disturbances associated with: (a) excessive body fat, (b) entrenched inflammation, (c) elevated blood cholesterol, (d) high triglycerides, (e) elevated LDL levels, (f) blood sugar dis-regulation, (g) cardiovascular risks, (h) kidney risks, (i) chronic tiredness and fatigue, (j) entrenched inflammation, and (k) key underlying factors of aging.*
  • Quickly achieve and maintain ideal weight and body mass index (BMI) outcomes, even for the more stubborn overweight cases.*
  • Reduce underlying causations to entrenched inflammation.*
  • Facilitate more efficient fatty acid beta-oxidation (fat burning).*
  • Promote normalization of high blood pressure and ACE, by helping to counter unhealthy elevated angiotensin levels.*
  • Help downregulate excessive kidney ROS and unhealthy NF-kB activity especially in long-term ingrained conditions of kidney stress.*
  • Promote swift normalization of HbA1c, blood sugar levels and insulin regulation.*
  • Help resolve the key underlying factors causing plaque and blood clots.*
  • Effectively helps suppress: (1) Advanced Glycation End products (or AGEs, which is regarded by medical authorities as the primary driving force to the aging process), and (2) the assaults and injuries to the critical inner lining to blood vessels*
  • Help facilitate normal heart rhythm.*
  • Raise cardiac and muscle mitochondrial ATP production via upregulating pyruvate dehydrogenase complex (PDC).*
  • Attain multiple times the blood levels of active berberine compared to standard oral berberine formulas.*

  To achieve all of the above, Metabolic MD™ incorporates all non-GMO ingredients in a proprietary synergistic ratio* including:

  • Highly concentrated and standardized liposomal Berberine.*
  • Highly concentrated and standardized Green Coffee Extract containing 50% Chlorogenic acid (CHA) and < 2% caffeine.*
  • Highly concentrated and standardized Citrus aurantium extract → A mild modulator of both favorable α-adrenoreceptor (α1A-AR) and β-adrenoreceptor activity.*
  • Standardized Irvingia gabonensis seed extract .*
  • Highly concentrated and standardized Camellia sinensis extract containing 60% EGCG.*
  • 200mg L-Carnitine per serving.*
  • 100mg Benfotiamine - A highly bioavailable vitamin B-1 per serving.*
  • Sunflower Lecithin and medium chain triglycerides.*

  Metabolic MD™ is imbued with exceptional potency. Metabolic MD™ WAS CONCEIVED AND FORMULATED TO BE THE MOST POTENT SUPPLEMENT IN ITS CLASS (i.e., metabolic modulators) IN ORDER TO ADDRESS A WIDE-SPECTRUM OF METABOLIC RISKS AND PROMOTE HOMEOSTASIS NORMALIZATION PERMANENTLY WHEN TEAMED WITH THE 5 POINT MODEL SYSTEM – E.g., resistant obesity, entrenched inflammation, non-responsive/resistant blood fat and blood sugar regulation, complex cell metabolism dysfunction, multiple cardiovascular risks and deeply disrupted energy (ATP) production. One or more of these conditions are now the hallmark to many/most patients walking into the integrative physician’s office. This formed an urgent need for a nutraceutical product as potent and versatile as Metabolic MD™.*

• HOW WILL MY PATIENTS KNOW WHEN THEIR METABOLISM IS RESPONDING TO METABOLIC MD?
• We are getting subjective reports that after the product has been taken for a few weeks, patients start feeling increased body heat (they feel a bit warmer), especially at night. One case reported they had to cool their bedroom by an extra degree to stay comfortable as they slept, a likely sign that thermogenesis was in higher gear.*
• We are also receiving reports of rapid reversal of entrenched hyperglycemic cases after only a few days of taking 1 capsule b.i.d. Symptoms included the milder symptoms of classical hypoglycemia - subtle shakiness, mild heart palpitation with hunger urges, mental dullness, fatigue, mild dizziness, mild temporary chest restriction, frequent yawning or air hunger, or feeling hung-over. In such events, relief would come quickly with just a few sips of orange juice or a handful of grapes. Because the drop in blood sugar levels to the normal range was so abrupt for metabolisms long adapted to hyperglycemic states, patients were instructed to temporarily lower their dosage to only one capsule daily. Then for those with glucometers, they were instructed to frequently track their blood sugar levels, or symptoms, or both in order to more smoothly and gradually manage the restoration of their blood sugar homeostasis within normal ranges. For example, (i) they were instructed to eat a small amount of fresh grapes or drink 2oz. to 4oz. orange juice if they dipped into hypoglycemia, but no reports surfaced as of this writing likely because (ii) they were also instructed as prophylaxis to eat small frequent high-protein vegetarian meals or drink smoothies (6oz.), at least 6 times daily. Regular meal times were maintained as well. Calorie intake should actually be sufficient to sustain long-term fat loss while sparing body protein stores. So do not worry about the frequency of these small protein-rich vegetarian meals of smoothies. Too rapid a blood sugar drop even if into the normal ranges in patients long suffering from hyperglycemia can be jarring for some.
• For patients suffering from long-term metabolic derangements: (a) reducing dosage of  Metabolic MD™ is the simple solution to just one per day, and start with only one capsule daily for at least 1 week; (b) if hypoglycemic events do occur, pre-instruct patients to simply carry with them a handful of raisins, or find a small amount of some healthy juice to drink; however, (c) best management over the entire adjustment period includes incorporating the use of small frequent meals. Together with the 5 Point Model System, many of these cases should eventually be able to return to self-sustaining blood sugar homeostasis for good within 12 weeks.*
• But the best objective means to track your patients' progress and best manage them, in our opinion, is to perform regular BMI studies. These measurements only take a few seconds, and then the software interprets the defining results in seconds. What you want to look for first is: (1) What is the patient's Phase Angle Index (PAI)? Is it above 7.5 or not? At-a-glance, there may be no other more important single biomarker than this to tell you (i) what the average cellular energy levels are and (ii) what the metabolic efficiency is systemically. (2) Is the intracellular water relatively greater than the extracellular water levels? (3) Is the patient dehydrated according to their expected total body water content? (4) Is the patient possibly Essential Fatty Acid (EFA) deficient (i.e., are they below healthy body fat levels)?*
• More on BMI values and what they all mean is next.

SPECIAL ADVISORY:

Metabolic MD™ is contraindicated when a patient is dehydrated, especially with below normal body fat as detected by BMI screening (e.g., elite athletes who are essential fatty acid deficient; malnourishment syndromes; cachectic states, chronic states of hypoglycemia, etc), and even more especially if they are calcium and magnesium deficient as ascertained via SpectraCell blood analysis. Correct the dehydration, essential fatty acid deficiency and mineral deficiencies first before beginning  Metabolic MD™. Patients who suffer from chronic hypoglycemia should not take Metabolic MD™until corrected and then only if medically indicated. Pregnant and lactating patients should not take this product. Folks who monitor their blood sugar levels frequently should proceed with only one capsule daily for two weeks, and then check in to have their physician alter dosages where appropriate. 

HOW WILL MY PATIENTS KNOW WHEN THEIR METABOLISM IS FINALLY AT ITS OPTIMAL FUNCTION?

• ANSWER: Optimal Regenerative Medical Objectives According to the 5 Point Model System - (A) Phase Angle Index (PAI) determined via standard BMI measurements should be 7.5 or greater; (B) Total Body Water (TBW) should be at upper 75% quartile; (C) Coupled to this, Intracellular Water (IW) should be at upper 75% quartile; and (D) Extracellular Water (EW) should be within normal range and never indicate an out of range IW/EW ratio; (E) Lean protein mass (LPM) should also be at the upper 75% quartile range; (F) White Adipose Tissue (WAT) should be at or below 50% quartile, and (G) Brown Adipose Tissue (BAT) should be at or below 50% quartile range.
• Coupled to the above BMI scores, normal Blood Pressure, Blood Sugar, Triglycerides, Cholesterol and LDL levels must be attained, and upper 75% quartile scores for HDL attained.
• Basal Urine should be >6.7 pH; basal axillary temperature should be = 98.0 degrees F, plus or minus 0.2 degrees F. When urine is consistently on the acidic side, and the patient is consistently eating an alkaline diet and drinking alkaline electrolyte-rich water at proper levels, suspect intracellular oxygen deficiency, which is most simply and quickly corrected by EWOT.
• The above optimal levels are not achievable without proper exercise and VO2max, which fundamentally contributes up to 70% of these optimal levels.
• There are several excellent choices when it comes to implementing appropriate exercise instructions and options for you patients...
• The simplest and cheapest is called "jarming". This is simply brisk power walking and slow deep breathing while raising/swinging the arms above shoulder level. This is a great exercise if the patient is not suffering from shoulder, hip, knee or ankle musculo-skeletal injuries or disfunctions.
• The optimal exercise technique to use, without exception, is a low-impact stationary exercise that incorporates oxygen called Exercise With Oxygen Therapy or EWOT (according to Manfred von Ardenne's Oxygen MultiStep Therapy). This specific type of low-impact aerobic, lactate eliminating, alkalizing, maximizing cellular oxygenation (VO2max) exercise is key to achieving the extraordinary regenerative states seen in the long-living, and restoring advanced degenerative states to optimal metabolic performance. Simply stated EWOT turns around the really sick patients on a dime, so to speak, when properly supported and supervised. There are equivalent techniques for the non-ambulatory cases as well.
• To guide the best management and intensity of these two forms of exercise above, there are: (1) Age-Adjusted Aerobic Limit, which is calculate by taking 220 minus the patients' age, then reduced by another 25%, as their maximal heart rate to maintain during aerobic exercise, or (2) the Maximum Aerobic Function Heart Rate (MAF HR) technique or (3) routines of high intensity interval training (HIIT) for those athletically inclined (e.g., bouts of 30 seconds all-out intense aerobics followed by 90 seconds complete rest, repeated 8 cycles, or variations on same formula theme, etc.). See below for more information.

EXAMPLES OF CASE HISTORIES

• For a first example, patient was recently shifted to oral hypoglycemic drug. Over two weeks, first morning glucose value remained 180mg%, +/- 10mg%. After two days of taking 1 capsule Metabolic MD twice daily, the patient reported sleeping better than before and more energized in the afternoons than in many years, but also that their first morning blood sugar level fell to 114mg%. That's a 66mg% drop in just two days - understandably, the patient felt a little "hung-over". Therefore, the dosage of Metabolic MD was reduced to just one daily for 2 weeks, then to be increased to one twice daily for two weeks and re-evaluate. 
• For a second example, patient's PAI is below 7.5. (A) Question them about their electrolyte-rich water intake, alkaline forming diet and exercise regimen. (B) Then have them measure their basal urine pH (first morning catch). Assuming they are eating an alkaline forming diet and their urine is at or below 6.6 pH, suspect (i) low reserves of cellular oxygen and (ii) deficient levels of intracellular electrolytes (remember, alkaline electrolytes like potassium are essential for a majority of enzyme functions). Have these adult patients: (1) start a low impact exercise program or EWOT, (2) drink 75oz. to 100oz. per day electrolyte-rich potassium water and (3) take the full recommended daily serving of Essentials 5 in 1™ to promote activation of their intracellular enzymes.*
• If this protocol above does not correct the basal acidic pH urine readings, suspect infection.*
• For a third example at the other end of the spectrum, Patient's PAI is in the 6.5 range. If the patient's IW is greater than their EW level, and their BMI does not indicate dehydration nor total body water excess, this suggests that the patient may be an ideal candidate to quickly correct and enhance their metabolism with Metabolic MD™ supplementation. These patients may be able to attain a PAI at 7.5 or greater within a month if they take the recommended daily dose of Metabolic MD™ and implement daily jarming or EWOT.*
• To illustrate a bit further in such cases which suggest above average cell-oxygen utilization, occasionally some folks will go to bed having weighed themselves at, say, 130LBs, and compulsively weigh themselves first thing in the morning again, only to discover that they weigh 132LBs! Although rare because most folks wake up at least slightly dehydrated, this peculiar weight gain can only be water weight gain made from oxygen breathed in during sleep, since adipose tissue cannot possibly achieve that growth rate overnight! But is this excess water measured through the BMI excess IW or EW? If the latter, check kidney and heart function or suspect inflammation coming from microbiota dysbiosis, or deeper disturbances in the internal microbiome. In such cases, we often find our Metabolic MD™ (1 per meal or 2 at both breakfast & lunch) to be indispensable.
• If the former (their IW levels are higher than their EW levels and they are not out of range high in total body water), Metabolic MD™, RxCoQ-CF™ and Magnesium Rx™ taken at low maintenance levels should result in superior metabolism when supported with low impact exercise.*
• For perspective, think of these cases this way (i.e, any patients with higher quartile IW than EW, alongisde normal levels of total body water content) - The patients' IW levels are tilted in their metabolic favor. Why is this? Well, in order for the IW to be at high levels, with normal range EW and total body water, there are limited reasons why this state occurs. Either (1) the electrolytes from the diet have been near perfect for a long time, and/or (2) their intracellular oxygen saturation has been optimal for a long time. In either case, oxygen utilization is likely at optimal efficiency, and the consequent/obligatory production of intracellular water is at maximum. The only other possibility is a severe inversion of the sodium/potassium ratio, which occurs in chronic degenerative states, but then there will be the clinical indication of such, and/or the EW and Total Body Water content will be out of normal ranges as well.
• Therefore, assuming the cells collectively are in proper electrolyte balance and at maximal intracellular water levels, with sufficient exercise and supplements as provided above, the resulting thermogenesis and ATP generation should necessarily skyrocket. This will enable not only ideal fat burning, but also sequential BMI measurements may show a net increase in lean protein mass as continued exercise is practiced. BMI software calculations are formulated to reveal both muscle mass gain and organ mass gain. One ratio to keep in mind is that when lean protein mass goes up, about 20% is increase in working organ cells. When adipose cells infiltrate organs, it is a major contributor to aging. That part of the organ replaced with adipose cells is no longer working to produce hormones or growth factors or both, whatever that specific organ is supposed to do in its youthful state. In the case of endocrine organs, that part of the endocrine gland is unable to make hormones. When the BMI reflects a net increase in lean protein mass, 20% of that may indeed be a return to function of organ functions. This is akin to tissue restoration like that of the extremely fit who build proteinaceous muscle tissue, only in this case, it is proteinaceous organ tissue. When increased lean protein mass occurs, it is a sign of true regenerative medicine at work, and the PAI should also reflect increasing levels as well, a sign ATP generation is optimizing across the entire body.*
• For a fourth example, if the patient is dehydrated to start, that information is vital, because it likely indicates they are not drinking their required daily quota of electrolyte-rich water. Other reasons could include either a deficiency or inefficiency in oxygen metabolism, especially if the patient is over 45 years of age. Recall that as oxygen is breathed in, it will of course produce ATP and burn fat through beta-oxidation, but then it also will produce needed internal (intracellular) water. Without proper cell hydration, cell metabolism will go awry. BMI measurements will capture this situation nicely. This is perhaps one key reason almost always overlooked why older folks are so prone to dehydration - most of them are oxygen deficient at the cell level or are utilizing oxygen inefficiently, and their BMI will usually reflect relatively low intracellular water reserves. This kind of insidious dehydration cases even arise in well-hydrated patients who poorly utilize oxygen metabolically. One variable is the dehydrating effects of night-time air-conditioning which acts as a dehumidifier on the lungs. Consider RxCoQ-CF™ and Magnesium Rx™ in addition to adequate consumption of electrolyte-rich water and oxygenating jarming.*
• For a fifth example, high EW levels especially when coupled to excessive total body water levels may indicate entrenched inflammatory states from insidious infection. Dysbiosis is but one example. This entrenched inflammatory state often accompanies cardiac and or kidney dysfunction. Alongside your medical management of such situations, Metabolic MD™ is an ideal supplement to speed return of homeostasis because it promotes significant anti-inflammatory actions.*
• For a sixth example, patient has a history of liver and bowel congestion and inflammation. Upon taking 1 capsule of Metabolic the patient experienced headaches and nausea. Detoxification procedures were implemented to upregulate Phase 2 Liver Conjugation (Liver MD™, Purebiotic™, Essentials 5 in 1™ and 100oz. of electrolyte-rich water consumed daily), and the patient was able to resume Metabolic MD without further symptoms.

SAFETY

All MD Prescriptives™ products are formulated with safety in mind. Our carefully selected content amount of the bioactive constituent in green tea - EGCG - is a great example. We formulated Metabolic MD™ with sufficient levels of green tea to acquire therapeutic levels of EGCG, but still keep the maximal daily serving amount well below the established observed safe levels (OSL) threshold provided by the authoritative literature. For an example of interest, reports rarely surface indicating daily consumers of green tea in excessive amounts may be at risk for elevated liver enzymes, a condition which fully reverses upon discontinuing their high consumption of green tea. In one recent case, up to 1600mg daily of EGCG may have been consumed over four months depending upon the brand of green tea used. The amount consumed in this case likely greatly exceeded the limit of 700mg/day OSL.*  

SPECIAL NOTE

At recommended dosages, all ingredients in Metabolic MD™ are not known to incur negative drug-to-drug interactions (see references below). There is one report that Metformin is best NOT taken at the same time as green tea, since EGCG may impair bio-absorption of Metformin. This is easy to manage, since Metformin ER (extended release) is often taken 12 hours apart first thing in AM and late PM. Whereas Metabolic MD™ is best taken with meals. By this timing difference as to when each is best administered, bio-absorption rates of either agent are not in the same proximity of the intestinal tract to interfere with each others absorption.*

We recommend closer monitoring of patients taking medications at risk for inducing unhealthy liver alterations.*

Contraindications

• Women who are pregnant or breast-feeding, patients with pacemakers or ICDs, patients with history of angina, patients under 18 years of age, patients with adrenal exhaustion or low adrenal reserve, and people with history of allergies to any of the included ingredients (e.g., citrus) should not take Metabolic MD™. For example, patients who may be sensitive to some types of citrus may notice a mild skin rash, or mild burning of skin, or both. If these symptoms arise, simply discontinue product. Be aware of hypoglycemic symptoms, and reduce dosage if encountered, plus eat more frequent mini-meals high in vegetable proteins.

Recommended General Guidelines For Adult Dosages

• Start with one capsule at breakfast for 1 week.
• Then, up to 1 capsule at both breakfast and lunch (2 daily). Reduce to prior dosage if hypoglycemic symptoms arise, and counter by eating more frequent, smaller snack/meals.
• After 2 weeks of easily tolerating 1 capsule taken twice daily, either stay at this well-tolerated dosage, or speed results by taking one each main meal (3 daily). Either stay at this dosage level, or if optimum results are desired over the shortest time frame, test yourself as whether taking 2 capsules at breakfast and 2 at lunch are well tolerated. Simply reduce dosage to prior well-tolerated dosage if hypoglycemic symptoms are encountered.

By Weight - Adult (>75KG // > 165lbs) Optimal Dosage Schedule - Start with 1 capsule at breakfast and 1 at lunch for first week, then reduce caffeine consumption, and take 1 capsule with breakfast, lunch and dinner for another week. Starting week 2 if tolerance and energy levels are good, increase dosage to a maximum of 2 capsules at breakfast and 2 at lunch. If too much energy or other symptoms arise, reduce to prior dosage that did not cause symptoms, e.g., 1 capsule daily or twice daily if energy surges too rapidly.
By Weight - Adult (<75KG // <165lbs) Recommended Dosage Schedule - Take 1 capsule at breakfast and 1 at lunch.
Maintenance dosage for adults - 1 to 2 capsules daily in divided dosages. NOTE: Patients may continue to notice improvements in their BMI and or weight profile, even when on maintenance dosages, albeit slowly.

• We recommend if caffeine consumption has not yet been reduced, to take all dosages of Metabolic MD™ before 3:00PM. However, reports are coming in that the anxiolytic properties of the ingredients within Metabolic MD™ are helping to promote deeper rest at bedtime as well.
• Note that caffeine beverages act as synergists to our low-caffeine containing Metabolic MD™. Drinking organic coffee can make you stay healthy by heading off many risk factors critical to overall good health and longevity, but don't overdo it!*
• Consumers who drink multiple caffeinated beverages daily should only start out taking 1 capsule daily of Metabolic MD™ until they lower their caffeine intake approximately 25%. For example, after starting Metabolic MD™, those consuming too much caffeine may find their heart occasionally racing, indicating its time to cut back on caffeine consumption. According to the FDA, a 12 ounce can of a caffeinated soft drink typically contains 30 to 40 milligrams of caffeine, an 8-ounce cup of green or black tea 30-50 milligrams, and an 8-ounce cup of coffee closer to 80 to 100 milligrams. Caffeine in energy drinks can range from 40-250 mg per 8 fluid ounces! This is the reason why Metabolic MD's™ powerful formula was designed to contain only minimal amounts of caffeine (< 4mg per capsule).*
• NOTE: Once the patients' metabolism becomes fully restored to normal, and they are exercising regularly, maintenance dosages will add excellent insurance to help to keep them there for about 1/2 their initial cost. That is, each bottle when consumed for maintenance, now lasts for at least 60 days reflecting a +50% cost-savings.

• For complicated metabolic states, when tolerance indicates it is allowable to take at both breakfast and lunch, this energizing formula will promote outstanding metabolic efficiency and healthier BMI status in 8 to 12 weeks.* Metabolic MD™ synergists to promote speedier results include Essentials 5 in 1 DR™, Magnesium Rx™, RxCoQ-CF™ and Omega Rx™.

• Patients should be instructed to expect energy increases, and to use their new-found energy surges to initiate or maintain a safe, regular exercise program keeping to the guidelines provided by Maximum Aerobic Function Heart Rate (MAF HR), or better yet, 25 minutes daily of low-impact stationary exercise with oxygen therapy (EWOT) while maintaining their heart rate at 220 minutes their age, minus 20% more.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

• REFERENCES

• Manfred von Ardenne, Oxygen Multistep Therapy: Physiological and Technical Foundations. ISBN-13: 978-0865773776 or ISBN-10: 0865773777
• Electrolyte-Rich Water can be made easily with 1-2 TBLSPs of Himalyan Pink Salt into 1/2 gallon purified water plus fresh lemon juice to buffer taste. Drinking up to 100oz per day is a proper objective for most adults.
• For more information on MAF HR, see: https://philmaffetone.com/white-paper-introduction-maf-maximum-aerobic-function/For more information on EWOT, contact SaJune Institute of Restorative and Regenerative Medicine.
• For FDA Caffeine data see: https://www.fda.gov/ForConsumers/ConsumerUpdates/ucm350570.htm
• Hu J, Webster D, Cao J, Shao A. The Safety of Green Tea and Green Tea Extract Consumption in Adults – Results of a Systematic Review. Regul Toxicol Pharmacol. 2018 Jun;95:412-33.
• Albassam AA, Markowitz JS. An Appraisal of Drug-Drug Interactions with Green Tea (Camellia sinensis). Planta Med. 2017 Apr; 83(6):496-508. 
• Knop J, et al. Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein. PLoS One. 2015 Oct 1;10(10):e0139370.
• Buchanan B, et al. Comparative pharmacokinetics and safety assessment of transdermal berberine and dihydroberberine. PLoS One. 2018; 13(3): e0194979.
• Guo Y, Pope C, Cheng X, Zhou H, Curtis D. Dose-response of Berberine on Hepatic Cytochromes P450 mRNA Expression and Activities in Mice. Klaassen J Ethnopharmacol. Author manuscript; available in PMC 2012 Oct 31. Published in final edited form as: J Ethnopharmacol. 2011 Oct 31; 138(1): 111–118.
• Suntar I, Khan H, Patel S, Celano R, Rastrelli L. An Overview on Citrus aurantium L.: Its Functions as Food Ingredient and Therapeutic Agent.
  Oxid Med Cell Longev. 2018; 2018:7864269.

• Wang J, Wang H, Peng Y, Wang GJ, Hao HP.  Isochlorogenic acid A affects P450 and UGT enzymes in vitro and in vivo. Chin J Nat Med. 2016 Nov;14(11):865-870.

• More references coming soon

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NanoZeolite MD™

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• Description
• FAQ
• Webinar
• Whitepaper

• MD Prescriptives’™ NanoZeolite MD™ is made from a water suspension of natural food-grade zeolite which is sourced from uncontaminated clinoptilolite clay. More specifically, the primary bioactive ingredient found in NanoZeolite MD™ is composed of a silicate mineral complex featuring particle sizes with superior absorption high-surface energy over common food-grade zeolite products. The particle size range spans the upper nanometer to lower micrometer size ranges, which 'defines' the absorption powers (sorption capacity or biosorption performance) of the “micronized” zeolite particles as 'highly bioactive'.^1,2 These highly bioactive micronized zeolite particles efficiently promote removal of noxious body loads containing harmful chemicals (i.e., xenobiotic elimination), heavy metals (i.e., chelation), radionuclides (i.e., decorporation), offensive microbial secretions (i.e., exoprotein elimination), and even undesirable microbes (i.e., microbiota purification).^{3,4 *}

  Safety and Efficacy

  Zeolite is listed under the FDA’s G.R.A.S. list.⁵ Zeolite possesses powerful cation-exchange physics, making it ideal to grab onto (i.e., chelate) noxious cations.⁶ It has long been safely used as a feed additive for livestock to boost their health when confronting select health challenges.⁷ It is important that the clinoptilolite raw source material is tested for heavy metal contaminants prior to being manufactured into a nutraceutical product intended to induce chelation and decorporation in your patients.^8*

  Promotes Detoxication

  At the end of this discussion, we present two compelling unpublished clinical results conducted at a certified laboratory illustrating the amazing ability of the primary ingredient in NanoZeolite MD™ to induce highly cost-effective chelation and decorporation in your patients. You will see how this primary ingredient mobilizes deeply entrenched radionuclides and heavy metal stores when administered in the proper dosages.

• What we do know from decades of remediation-related and livestock-related studies, is that food-grade zeolite offers great promise when used as a food supplement. Beyond 'food-grade' zeolite, highly bioactive micronized zeolite studies are just now emerging. Collectively these studies indicate that the primary ingredient in NanoZeolite MD™ may be safely used to help eliminate from your patients the following list of heavy metals:^*

  1. Mercury,^9,10,11,12
  2. Arsenic,^13,14
  3. Lead (Pb),^15,16
  4. Chromium (the toxic form - CrVI),¹⁷
  5. Cadmium (Cd),^18,19,20,21
  6. Nickel (Ni),²² as well as
  7. Radionuclides (radioactive heavy metals).^23,24,25

  Indications:^*

  • Neurological disorders^26,27,28
  • History of smoking²⁹
  • History of regular alcohol consumption³⁰
  • Metal dental fillings
  • Exposure to heavy metals
  • High fish ingestion
  • Intestinal disorders, especially dysbiosis and diarrhea
  • Antimicrobial resistance^31,32
  • Microbial secretion detoxication
  • Immunological associated inflammatory states

  Supports a Healthy Microbiota

  A large body of peer-reviewed evidence indicates the primary ingredient in NanoZeolite MD™ beneficially modulates the intestinal microbiota in at least three key ways.^33,34 First, the primary ingredient in NanoZeolite MD™ is known to promote the clearance of undesirable bacteria and viruses, plus effectively suppress proliferation of non-beneficial microbes such as Clostridia, E. coli, Klebsiella, Enterobacter, Salmonella and Proteobacteria. Secondly, the primary ingredient in NanoZeolite MD™ has been shown to promote the health imbuing rapid growth of two key beneficial probiotic genus, both Lactobacillus spp., as well as Bifidobacterium spp.^{35,36,37,38,39,40} And thirdly, the primary ingredient in NanoZeolite MD™ promotes pancreatic enzyme activity, while helping to eliminate intestinal toxemia, thereby favorably modulating the entire intestinal milieu.^41,42*

  Supports Normal Cellular Growth

  Natural food-grade zeolite is known to promote healthy modulation of receptor sites and genes associated with unhealthy cell growth. Natural food-grade zeolite accomplishes this while simultaneously reducing lipid peroxidation. The significance of this combined feat is that it promotes overall improvement in the health status and longevity in murines suffering from unhealthy cell growth.^43,44,45,46*

  With the emergence of highly bioactive micronized zeolite, NanoZeolite MD™ may now become one of the most promising healthy cell growth modulators available to the clinical practice.*

• Supports Healthy Immune System Functions

  Many immune disorders center around excessive inflammation processes. As revealed in avian studies, one highly useful use of natural food-grade zeolite supplementation is its ability to help neutralize undesirable pro-inflammatory radicals and noxious microbe secretions such as mycotoxins, LPS and aflatoxin.^47,48,49,50 Interestingly, natural food-grade zeolite is an excellent chelator and eliminator of pro-inflammatory histamine.⁵¹ But beyond these lesser potent food-grade zeolite products, dietary supplementation with highly bioactive micronized zeolite offers the promise of an unexcelled means to: (A) improve and enhance several key immune functions, while (B) beneficially modulating inflammatory pathways.⁵² Specifically, the primary ingredient in NanoZeolite MD™ is known to: (1) increase the numbers of foci-regional macrophages and (2) promote their defensive respiratory burst capability in murines.^53,54*

  Promotes Antioxidant Functions

  Zeolite's superior antioxidant properties and beneficial influence on RedOx homeostasis are well-known. For example, zeolite significantly decreases ROS production and suppresses Nitric Oxide Synthase (NOS) while significantly increasing the bioactivity of glutathione peroxidase, catalase, S.O.D. and total antioxidant capacity.^55,56* Interestingly, one study suggests that to obtain best results, it may be wise to only administer highly bioactive micronized zeolite by itself, that is, not in direct combination with other anti-oxidants.⁵⁷

  Zeolite Challenge Test (To Provoke Decorporation as well as Deep Tissue Chelation) - Two Case Outcomes*

  1. A 37-year old male submitted a baseline urine specimen on June 09^th, 2016 to screen for heavy metals. Testing for a complete spectrum of heavy metals was undertaken by Access Medical Labs in Jupiter, FL. The lab determined there were only two heavy metals that were elevated out of twenty-one heavy metals tested. The results were as follows:

     • 3.95ug/g Niobium (Normal Range 0-0.5ug/g)
     • 0.5ug/g Thorium (Normal Range 0-0.1ug/g)

     Post-Testing - On June 13^th, 2016, after taking the primary ingredient of NanoZeolite MD™ at ten drops twice daily sublingual for 5 days, he again provided a urine sample for analysis to Access Medical Labs. Surprisingly, his heavy metal urine load (both in quantity as well as in spectrum of heavy metals detected) jumped significantly as excretion ensued (illustrating efficacious Mercury chelation as well as decorporation of Thorium) to the following values:

     • 12.56ug/g Bismuth (Normal Range 0-10ug/g)
     • 12.23ug/g Mercury (Normal Range 0-10ug/g)
     • 8.11ug/g Niobium (Normal Range 0-0.5ug/g)
     • 4721ug/g Rubidium (Normal Range 0-4000ug/g)
     • 1.3ug/g Thorium (Normal 0-0.1ug/g)
     • 1.4ug/g Tungsten (Normal Range 0-1ug/g)

  2. A 57-year old male provided a urine sample on December 27, 2016 to Access Medical Labs. Out of Twenty-one heavy metals tested, none were shown to be above normal range. For example, at that time Mercury tested in the normal range at 3.02ug/g. After seven days of consuming the primary ingredient found in NanoZeolite MD™ at 10 drops twice daily, the following heavy metal was detected out of twenty-one tested:

     • 22.71ug/g Mercury (Normal Range 0-10ug/g)

  In conclusion, the primary ingredient in NanoZeolite MD™ has been shown to promote heavy metal decorporation even when baseline urine samples detect no heavy metals present. At 10 drops taken sublingually twice daily for 5 to 7 days, the zeolite challenge test may unlock stores of heavy metals from their deep tissue resting places for urinary excretion.*

  It may take up to 30 to 60 days at the dose of 10 drops twice daily to complete the decorporation process, depending upon the deep tissue saturation loads. However, prolonged supplementation with micronized zeolite is to be discouraged due to its eventual tendency to remove desirable macrominerals from the body.^58,59*

  Daily dosages may be adjusted up or down to adjust to tolerance and vary the speed of elimination.*

  Generally, 30 consecutive days of taking NanoZeolite MD™ sublingually is sufficient to maximize its healthful benefits. But repeated urinary screenings for heavy metals will typically confirm length of treatment required.*

  *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

  References

  1. Hall JB, Dobrovolskaia MA, Patri AK, McNeil SE. Characterization of Nanoparticles for Therapeutics. Nanomedicine (Lond). 2007 Dec;2(6):789-803.
  2. Horiba Particle Size Distribution Analyzer LA-950 V2; Project No.: 009-1144. ID# 201605261039963. Assay No.: E261/16. Hazen Refractive Index - Operator: A. Cavendor. Smallest zeolite particles detected were ≤877 nanometers (≤0.877µm) in diameter. Median particle size range ~10.80 micrometers. Hazen Research, Inc. May 5th, 2016.
  3. Prasai TP, et al. Biochar, Bentonite and Zeolite Supplemented Feeding of Layer Chickens Alters Intestinal Microbiota and Reduces Campylobacter Load. PLoS One 2016 Apr 26;11(4):e0154061.
  4. Hrenovic J, et al. Antimicrobial Activity of Commercial Zeolite A on Acinetobacter junii and Saccharomyces ceresvisiae. J Hazard Mater. 2010 Nov 15:183(1-3):655-63.
  5. U.S. Food & Drug Administration. Database of Select Committee on GRAS Substances (SCOGS) Reviews. Report No.: 61; ID Code: 73987-94-7; CFR Section: 182.2727; Year – 1979.
  6. Pabalan RT, Bertetti FP. Cation-exchange properties of natural zeolites. Nat. Zeolites 2001;45:453–518.
  7. Papaioannou D., Katsoulos P. D., Panousis N., Karatzias H. The role of natural and synthetic zeolites as feed additives on the prevention and/or the treatment of certain farm animal diseases: a review. Microporous Mesoporous Mater. 2005;84:161–70.
  8. Tao YF, Fang SY, Liu ZY, Wang Y, Zhu JH. Trapping the Lead Ion in Multi-Components Aqueous Solution by Natural Clinoptilolite. J Hazard Mater. 2010 Aug 15;180(1-3):282-8.
  9. Cabanero AI, Madrid Y, Camara C. Effect of Animal Feed Enriched with Se and Clays on Hg Bioaccumulation in Chickens: in vivo Experimental Study. J Agric Food Chem. 2005 Mar 23;(53(6):2125-32.
  10. Hou Y, Wu P, Zhu N. The Protective Effect of Clay Minerals Against Damage to Adsorbed DNA Induced by Cadmium and Mercury. Chemosphere. 2014 Jan;95:206-12.
  11. Mier MV, Callejas RL, Gehr R, Cisneros BEJ. Heavy Metal Removal with Mexican Clinoptilolite: Multi-Component Ionic Exchange. Water Res. 2001 Feb;35(2):373-8.
  12. Haidouti C. Inactivation of mercury in contaminated soils using natural zeolites. Sci Total Environ. 1997 Dec 3;208(1-2):105-9.
  13. Bilgin Simsek E, Avci Tuna AO, Beker U. A Statistical Approach for Arsenic Adsorption onto Turkey Clinoptilolite. Environ Sci Pollut Res Int. 2015 Mar;22(5):3249-56.
  14. Payne KB, Abdel-Fattah TM. Adsorption of Arsenate and Arsenite by Iron-Treated Activated Carbon and Zeolites: Effects of pH, Temperature, and Ionic Strength. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2005;40(4):723-49.
  15. Delavarian M, Hassanvand A, Gharibzadeh S. Increasing Performance in Children with ADHD by Trapping Lead with a Nano-Zeolite. J Neuropsychiat Clin Neurosci. 2013;25(1):E23.
  16. Orhan Y, Kocaoba S. Adsorption of Toxic Metals by Natural and Modified Clinoptilolite. Ann Chim. 2007 Aug;97(8):781-90.
  17. Vaca Mier M, et al. Heavy Metal Removal with Mexican Clinoptilolite: Multi-Componnent Ionic Exchange. Water Res. 2001 Feb;35(2):373-8.
  18. Faghir H, Hassanvand A, Gharibzadeh S. Removing Cadmium by Nano-Pore Zeolites to Decrease Aggressive Behavior, Stress, and Hyperactivity. J Neuropsychiat Clin Neurosci. 2013;25(2):E73.
  19. Pond WG, Yen JT. Protection by Clinoptilolite or Zeolite NaA Against Cadmium-Induced Anemia in Growing Swine. Proc Soc Exp Biol Med. 1983 Jul;173(3):332-7.
  20. Castalki P, Santona L, Enzo S, Melis P. Sorption Processes and XRD Analysis of a Natural Zeolite Exchange with Pb(2+), Cd(2+) and Zn(2+) Cations. J Hazard Mater. 2008 Aug 15;156(1-3)428-34.
  21. Chi SL, et al. [Effect of Nano Zeolites on pH, CEC in Soil and Cd Fractions in Plant and Soil at Different Cadmium Levels]. Huan Jing Ke Xeu. 2017 Apr 8;38(4):1654-66.
  22. Sprynskyy M, Buszewski B, Terzyk AP, Namiesnik J. Study of the Selection Mechanism of Heavy Metal (Pb2+, Cu2+, Ni2+, and Cd2+) Adsorption on Clinoptilolite. J Colliod Interface Sci. 2006 Dec 1;304(1):21-8.
  23. Forberg S, Jones B, Westermark T. Can zeolites decrease the uptake and accelerate the excretion of radio-caesium in ruminants? Sci. Total Environ. 1989;79:37–41.
  24. Mitrovic BM, et al. Comparative Study of (137(Cs Distribution in Broilers and Pheasants and Possibilities for Protection. Radiat Environ Biophys. 2012 Mar;51(1):79-84.
  25. Mitrovic B, et al. AFCF and Clinoptilolite Use in Reduction of (137)Cs Deposition in Several Days’ Contamination Broiler Chicks. J Environ Radioact. 2007;95(2-3):171-7.
  26. Schofield K. The Metal Neurotoxins: An Important Role in Current Human Neural Epidemics? Int J Environ Res Public Health. 2017 Dec 5;14(12). pii. E1511.
  27. Faghir H, Hassanvand A, Gharibzadeh S. Removing Cadmium by Nano-Pore Zeolites to Decrease Aggressive Behavior, Stress, and Hyperactivity. J Neuropsychiat Clin Neurosci. 2013;25(2):E73.
  28. Montinaro M, et al. Dietary Zeolite Supplement Reduces Oxidative Damage and Plaque Generation in the Brain of an Alzheimer’s Disease Mouse Model. Life Sci. 2013 May 20;92(17-19):903-10.
  29. Dogliotti G, et al. Natural Zeolites Chabazite/Phillipsite/Analcime Increase Blood Levels of Antioxidants. J Clin Biochem Nutr. 2012 May;50(3):195-8.
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