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REFERENCES

^AThe gut microbiota refers to every resident microorganism, both microbes and macrobes, living in a host.

1. Roger LC, et al. Examination of faecal Bifidobacterium populations in breast- and formula-fed infants during the first 18 months of life. Microbiology. 2010;156:3329–3341.Abstract/FREE Full Text
2.  Favier CF, et al. Molecular monitoring of succession of bacterial communities in human neonates. Appl Environ Microbiol. 2002;68:219–226. Abstract/FREE Full Text
3.  Mitsuoka, T. Bifidobacteria and their role in human health. Journal of Industrial Microbiology. 1990;6:263. https://doi.org/10.1007/BF01575871.
4.  Gill H, Prasad J. Probiotics, Immunomodulation, and Health Benefits. In: Bösze Z. (eds) Bioactive Components of Milk. Advances in Experimental Medicine and Biology. 2008;606. Springer, New York, NY.
5.  Macfarlane GT, Cummings JH. Probiotics and prebiotics: can regulating the activities of intestinal bacteria benefit health? BMJ. 1999;318:999.
6.  Gill H, Prasad J. Probiotics, Immunomodulation, and Health Benefits. In: Bösze Z. (eds) Bioactive Components of Milk. Advances in Experimental Medicine and Biology. 2008;606. Springer, New York, NY.
7.  Bartosch S, et al. Microbiological Effects of Consuming a Synbiotic Containing Bifidobacterium bifidum, Bifidobacterium lactis, and Oligofructose in Elderly Persons, Determined by Real-Time Polymerase Chain Reaction and Counting of Viable Bacteria (see Table 2). Clinical Infectious Diseases. 2005 Jan; 40(1):28–37. See: https://doi.org/10.1086/426027
8. Bottacini F, et al. Comparative genomics of the Bifidobacterium breve taxon. BMC Genomics. 2014;15:170.
9.  Chaplin AV, et al. Intraspecies Genomic Diversity and Long-Term Persistence of Bifidobacterium longum. PLoS One. 2015; 10(8): e0135658.
10. Bartosch S, et al. Microbiological Effects of Consuming a Synbiotic Containing Bifidobacterium bifidum, Bifidobacterium lactis, and Oligofructose in Elderly Persons, Determined by Real-Time Polymerase Chain Reaction and Counting of Viable Bacteria (see Table 2). Clinical Infectious Diseases. 2005 Jan; 40(1):28–37. See: https://doi.org/10.1086/426027
11. McFarland LV, et al. United European Gastroenterol J. 2016 Aug; 4(4): 546–561.
12. Meile L, Ludwig W, Rueger U, Gut C, Kaufmann P, Dasen G, Wenger S, Teuber M. Bifidobacterium lactis sp. nov., a moderately oxygen tolerant species isolated from fermented milk. Syst Appl Microbiol. 1997;20:57–64.
13.  Gill H, Prasad J. Probiotics, Immunomodulation, and Health Benefits. In: Bösze Z. (eds) Bioactive Components of Milk. Advances in Experimental Medicine and Biology. 2008;606. Springer, New York, NY.
14.  Lidbeck A, et al. Impact of Lactobacillus acidophilus Supplements on the Human Oropharyngeal and Intestinal Microflora. Scandanavian Journal of Infectious Diseases. 1987;19(5):531-7.
15.  Skrzypczak K, Gustaw W, Waśko A. Health-promoting  properties  exhibited  by Lactobacillus helveticus strains. ACTA ABP Biochimica Polonica. 2015;62(4): 713-20.
16.  de Vries MC, Vaughan EE, Kleerebezem M, de Vos WM. Lactobacillus plantarum—survival, functional and potential probiotic properties in the human intestinal tract. International Dairy Journal. 2006 Sep;16(9):1018-28.
17. Braat H, et al. Lactobacillus rhamnosus induces peripheral hyporesponsiveness in stimulated CD4⁺ T cells via modulation of dendritic cell function. The American Journal of Clinical Nutrition. 2004 Dec;80(6):1618–1625. See: https://doi.org/10.1093/ajcn/80.6.1618
18. Koll P, Mandar R, Marcotte H, Leibur E, Mikelsaar M, Hammarstrom L. Characterization of oral lactobacilli as potential probiotics for oral health. Oral Microbiol Immunol 2008:23:139–147.
19.  Chapat L, Chemin K, Dubois B, Kaiserlian D. Lactobacillus casei reduces CD8⁺ T cell‐mediated skin inflammation. European Journal of Immunology. 2004 Sep;34(9):2520-28.
20.  Hou J-c, et al. Effect of culturing conditions on the expression of key enzymes in the proteolytic system of Lactobacillus bulgaricus. J Zhejiang Univ Sci B. 2015 Apr; 16(4): 317–326.
21. Azizi F, Najafi MBH, Dovom MRE. The biodiversity of Lactobacillus spp. from Iranian raw milk Motal cheese and antibacterial evaluation based on bacteriocin-encoding genes. AMB Express. 2017; 7: 176.
22. Parada J.L., Caron C.R., Medeiros A.B.P., Soccol C.R. Bacteriocins from lactic acid bacteria: Purification, properties and use as biopreservatives. Braz. Arch. Biol. Technol. 2007;50:521–542.
23.  Ali Y, et al. Front Microbiol. 2014; 5: 98.
24. Molina-Gutierrez A, et al. In Situ Determination of the Intracellular pH of Lactococcus lactis and Lactobacillus plantarum during Pressure Treatment. Appl Environ Microbiol. 2002 Sep; 68(9): 4399–406. 
25.  See - The Regeneration Effect: A Professional Treatise on Self-Healing by Dr. John Apsley è https://www.amazon.com/Regeneration-Effect-Professional-Treatise-Healing/dp/B0029ZN6LY/ref=sr_1_5?keywords=John+Apsley&qid=1553438206&s=hpc&sr=8-5
26.  Griffiths MW, Tellez AM. Lactobacillus helveticus: The Proteolytic System. Front Microbiol. 2013;4:30.
27.  Wu Q, Tun HM, Law Y-S, Khafipour E, Shah NP. Common Distribution of gad Operon in Lactobacillus brevis and its GadA Contributes to Efficient GABA Synthesis Toward Cytosolic Near-Neutral pH. Front Microbiol. 2017;8:206.
28.  Centanni M, et al. Tumor Necrosis Factor Alpha Modulates the Dynamics of the Plasminogen-Mediated Early Interaction between Bifidobacterium animalis subsp. Lactis and Human Enterocytes. Appl Environ Microbiol. 2012 Apr;78(7):2465-9.
29.  Riveiere A, Selak M, Lantin D, Leroy F, Vuyst LD. Bifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut.; Front Microbiol. 2
30.  Liu H-X, Keane R, Sheng L, Wan Y-JY. Implications of Microbiota and Bile Acid in Liver Injury and Regeneration. J Hepatol. 2015 Dec;63(6):1502-10.
31.  He X, Slupsky CM, Dekker JW, Haggarty NW, Lönnerdal B. Integrated Role of Bifidobacterium animalis subsp. lactis Supplementation in Gut Microbiota, Immunity, and Metabolism of Infant Rhesus Monkeys. mSystems. 2016 Nov-Dec; 1(6): e00128-16.
32.  Gasbarrini G, Bonvicini F, Gramenzi A. Probiotics History. J Clin Gastroenterol. 2016 Nov/Dec;50 Suppl 2, Proceedings from the 8^th Probiotics, Prebiotics & New Foods for Microbiota and Human Health meeting held in Rome, Italy on September 13-15, 2015:S116-S119.
33.  Clemente JC, Ursell LK, Parfrey LW, Knight R. The impact of the gut microbiota on human health: an integrative view. Cell. 2012;148(6):1258–1270. doi: 10.1016/j.cell.2012.01.035.[PMC free article]
34.  Sghir A, Chow JM, Mackie RI. Continuous culture selection of bifidobacteria and lactobacilli from human faecal samples using fructooligosaccharide as selective substrate. J Appl Microbiol. 1998 Oct;85(4):769-77.
35.  Markowiak P,  Śliżewska K. Effects of Probiotics, Prebiotics, and Synbiotics on Human Health. Nutrients. 2017 Sep;9(9):1021.
36.  Patel R, DuPont HL. New Approaches for Bacteriotherapy: Prebiotics, New-Generation Probiotics, and Synbiotics. Clin Infect Dis. 2015 May 15;60(Suppl 2):S108-S121.
37. Cani PD, Neyrinck AM, Fava F et al. Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia 2007; 50: 2374–2383. 
38.  Liévin-Le Moal V, Servin AL. Clin Microbiol Rev. 2014 Apr; 27(2): 167–199. 
39.  Rocha-Ramírez LM, et al. Probiotic Lactobacillus Strains Stimulate the Inflammatory Response and Activate Human Macrophages. J Immunol Res. 2017; 2017: 4607491. 
40.  Plaza-Diaz J, Gomez-Llorente C, Fontana L, Gil A. Modulation of immunity and inflammatory gene expression in the gut, in inflammatory diseases of the gut and in the liver by probiotics. World J Gastroenterol. 2014 Nov 14;20(42):15632-49.
41.  Ayabe T, Satchell DP, Wilson CL, Parks WC, Selsted ME, Ouellette AJ. Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria. Nat Immunol. 2000 Aug; 1(2):113-8.
42.  Stappenbeck TS, Hooper LV, Gordon JI. Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells. Proc Natl Acad Sci U S A. 2002 Nov 26; 99(24):15451-5.
43.  Weaver CT, Harrington LE, Mangan PR, Gavrieli M, Murphy KM. Review - Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity. 2006 Jun; 24(6):677-88.
44.  Cash HL, Whitham CV, Behrendt CL, Hooper LV. Symbiotic bacteria direct expression of an intestinal bactericidal lectin. Science. 2006 Aug 25; 313(5790):1126-30.
45.  Macpherson AJ, Gatto D, Sainsbury E, Harriman GR, Hengartner H, Zinkernagel RM. A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria. Science. 2000 Jun 23; 288(5474):2222-6.
46.  See – Integrative Regenerative Medicine: Colloidal Regenerative Factors (cRFs) and The Regeneration Effect è  https://www.amazon.com/Integrative-Regenerative-Medicine-Colloidal-Regeneration-ebook/dp/B01EEPYJRQ/ref=sr_1_1?keywords=John+Apsley&qid=1553438206&s=hpc&sr=8-1
47.  Mammalian intestine contains a large diversity of commensal microbiota, which is far more than the number of host cells. See: Yousefi B, et al. Probiotics Importance and Their Immunomodulatory Properties. J Cell Physiol. 2019 Jun;234(6):8008-18.
48.  Patel R, DuPont HL. New Approaches for Bacteriotherapy: Prebiotics, New-Generation Probiotics, and Synbiotics. Clin Infect Dis. 2015 May 15;60(Suppl 2):S108-S121.
49.  Yousefi B, et al. Probiotics Importance and Their Immunomodulatory Properties. J Cell Physiol. 2019 Jun;234(6):8008-18.
50.  Llewellyn A, Foey A. Probiotic Modulation of Innate Cell Pathogen Sensing and Signaling Events. Nutrients. 2017 Oct; 9(10): 1156. 
51.  Houschyar KS, et al. Wnt Pathway in Bone Repair and Regeneration - What Do We Know So Far. Front Cell Dev Biol. 2019 Jan 7;6:170.
52.  Smelt MJ, et al. Probiotics can generate FoxP3 T-cell responses in the small intestine and simultaneously inducing CD4 and CD8 T cell activation in the large intestine. PLoS One. 2013 Jul 4;8(7):e68952.
53.  Ghoneum M, Felo N, Agrawal S, Agrawal A. A novel kefir product (PFT) activates dendritic cells to induce CD4+T and CD8+T cell responses in vitro. Int J Immunopathol Pharmacol. 2015 Dec;28(4):488-96.
54.  Lukic J, et al. Probiotics or pro-healers: the role of beneficial bacteria in tissue repair. Wound Repair Regen. 2017 Nov;25(6):912-922. 
55.  Oryan A, Alemzadeh E, Eskandari MH. Kefir Accelerates Burn Wound Healing Through Inducing Fibroblast Cell Migration In Vitro and Modulating the Expression of IL-1ß, TGF-ß1, and bFGF Genes In Vivo. Probiotics Antimicrob Proteins. 2018 Jun 8. doi: 10.1007/s12602-018-9435-6. [Epub ahead of print]
56.  Athiyyah AF, et al. Lactobacillus plantarum IS-10506 activates intestinal stem cells in a rodent model. Benef Microbes. 2018 Sep 18;9(5):755-60. 
57.  Liu J, et al. Antibiotic-Induced Dysbiosis of Gut Microbiota Impairs Corneal Nerve Regeneration by Affecting CCR2-Negative Macrophage Distribution. Am J Pathol. 2018 Dec;188(12):2786-99.
58.  See - The Regeneration Effect: A Professional Treatise on Self-Healing by Dr. John Apsley è https://www.amazon.com/Regeneration-Effect-Professional-Treatise-Healing/dp/B0029ZN6LY/ref=sr_1_5?keywords=John+Apsley&qid=1553438206&s=hpc&sr=8-5
59.  See – Integrative Regenerative Medicine: Colloidal Regenerative Factors (cRFs) and The Regeneration Effect è  https://www.amazon.com/Integrative-Regenerative-Medicine-Colloidal-Regeneration-ebook/dp/B01EEPYJRQ/ref=sr_1_1?keywords=John+Apsley&qid=1553438206&s=hpc&sr=8-1
60.  Tyagi AM, et al.The Microbial Metabolite Butyrate Stimulates Bone Formation via T Regulatory Cell-Mediated Regulation of WNT10B Expression. Immunity. 2018 Dec 18;49(6):1116-1131.e7.
61.  Gu RX, Yang ZQ, Li ZH, Chen SL, Luo ZL. Probiotic properties of lactic acid bacteria isolated from stool samples of longevous people in regions of Hotan, Xinjiang and Bama, Guangxi, China. Anaerobe. 2008 Dec;14(6):313-7.
62.  Biagi E, et al. Gut microbiota and extreme longevity. Curr Biol. 2016;26:1480-5.
63.  Kong F, Deng F, Li Y, Zhao J. Identification of gut microbiome signatures associated with longevity provides a promising modulation target for healthy aging. Gut Microbes. 2018 Aug 24:1-6.
64.  Santoro A, et al. Gut microbiota changes in the extreme decades of human life: a focus on centenarians. Cell Mol Life Sci. 2018 Jan;75(1):129-148.
65.  Deng F, Li Y, Zhao J. The gut microbiome of healthy long-living people. Aging (Albany NY). 2019 Jan 15;11(2):289-290.
66.  Allen SJ, et al. Health Technol Assess. 2013 Dec;17(57):1-140.
67.  Allen SJ, et al. Health Technol Assess. 2013 Dec;17(57):1-140.
68. ssel C, Sivignon A, de Wiele TV, Blanquet-Diot S. Foodborne enterotoxigenic Escherichia coli: from gut pathogenesis to new preventive strategies involving probiotics. Future Microbiol. 2017 Jan;12:73-93.
69.  Ruiz MJ, Colello R, Padola NL, Etcheverría AI. Rev Argent Microbiol. 2017 Apr - Jun;49(2):174-177.
70.  Plaza-Diaz J, Ruiz-Ojeda FJ, Gil-Campos M, Gil A. Mechanisms of Action of Probiotics. Adv Nutr. 2019 Jan 1;10(suppl_1):S49-S66.
71.  Im AR, Lee B, Kang DJ, Chae S. Skin Moisturizing and Antiphotodamage Effects of Tyndallized Lactobacillus acidophilus IDCC 3302. J Med Food. 2018 Oct;21(10):1016-1023.
72.  Slattery J, MacFabe DF, Frye RE. Clin Med Insights Pediatr. 2016; 10: 91–107.
73.  Mallappa RH, et al. Indian J Endocrinol Metab. 2012 Jan-Feb; 16(1): 20–27.
74.  Panebianco C, Andriulli A, Pazienza V. Microbiom. 2018; 6: 92. Published online 2018 May 22.
75.  Yao K, Zeng L, He Q, Wang W, Lei J, Zou X. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research. 2017 Jun 22; 23: 3044-3053.
76.  Nazir Y, Hussain SA, Hamid AA, Song Y. Biomed Res Int. 2018; 2018: 3428437.
77. Liu Y, Alookaran JJ, Rhoads JM. Nutrients. 2018 Oct; 10(10): 1537.
78.  Crabtree DPE, Herrera BJ, Kang S. The Response of Human Bacteria to Static Magnetic Field and Radiofrequency Electromagnetic Field. J Microbiol. 2017 Oct;55(10):809-15.
79.  Vasistha S, Garg A. Effect of Electromagnetic Radiation on Lactobacillus Species. J Chem Pharmaceut Res. 2016;8(7):123-6. See: http://www.jocpr.com/articles/effect-of-electromagnetic-radiation-on-lactobacillus-species.pdf
80.  Gray JM, Rasanayagam S, Engel C, Rizzo J. State of the Evidence 2017: An Update on the Connection Between Breast Cancer and the Environment Environ Health. 2017;16:94.
81. Gill H, Prasad J. Probiotics, Immunomodulation, and Health Benefits. In: Bösze Z. (eds) Bioactive Components of Milk. Advances in Experimental Medicine and Biology. 2008;606. Springer, New York, NY.
82. Braat H, et al. Lactobacillus rhamnosus induces peripheral hyporesponsiveness in stimulated CD4+ T cells via modulation of dendritic cell function. The American Journal of Clinical Nutrition. 2004 Dec;80(6):1618–1625. See: https://doi.org/10.1093/ajcn/80.6.1618
83. Rocha-Ramírez LM, et al. Probiotic Lactobacillus Strains Stimulate the Inflammatory Response and Activate Human Macrophages. J Immunol Res. 2017; 2017: 4607491.
84. Yousefi B, et al. Probiotics Importance and Their Immunomodulatory Properties. J Cell Physiol. 2019 Jun;234(6):8008-18.